Free radicals generated by oxidative stress cause damage that can contribute to numerous chronic diseases. Mammalian cells respond to this damage by increased transcription of cytoprotective phase II genes, which are regulated by NRF2. Previously, it has been shown that NRF2 protein levels increase after oxidative stress because its negative regulator, KEAP1, loses its ability to bind NRF2 and ...

Biodiesel consisting principally of monounsaturated fatty acid methyl esters (FAME) has been reported to have the optimal balance between cold flow properties and oxidative stability, therefore producing a superior fuel. In addition, treating biodiesel with antioxidants such as selenium (Se) also increases oxidative stability. Fuel properties including acid value (AV), cloud point (CP), iodine ...

SIRT1, the NAD+-dependent protein deacetylase, controls cell-cycle progression and apoptosis by suppressing p53 tumour suppressor. Although SIRT1 is known to be phosphorylated by JNK1 upon oxidative stress and subsequently down-regulated, it still remains elusive how SIRT1 stability and activity are controlled. Here, we have unveiled that CHFR functions as an E3 Ub-ligase of SIRT1, responsible ...

OBJECTIVES Oxidative stress has been implicated in the outcome of atherosclerotic plaques. However, at present, no data are available neither on the degree of plaque protein sulfhydryl groups oxidation nor on its relationship with plaque vulnerability. We investigated the entity of protein-SH oxidative modifications, focusing on low molecular weight thiols adduction, in human carotid plaque ext...

Electrochemistry (EC) coupled to mass spectrometry (MS) has already been successfully applied to metabolism research for pharmaceutical applications, especially for the oxidation behaviour of drug substances. Xenobiotics (chemicals in the environment) also undergo various conversions; some of which are oxidative reactions. Therefore, EC-MS might be a suitable tool for the investigation of oxida...

Lipid and protein oxidation decreases the shelf-life of foods and may result in formation of end-products potentially detrimental for health. Consumer pressure to decrease the use of synthetic phenolic antioxidants has encouraged identification of alternative compounds or extracts from natural sources. We have assessed whether inclusion of dried vegetable powders improves the oxidative stabilit...

Commercially prepared and packaged soybean ::md cottonseed salad oils from several different processors were evaluated penodically during storage for 12 months. Panially hydrogenated and winterized soybean oils, as well as unhydrogenated soybean salad oils. were stored in bottles and cans at i8 and 100 F. Control samples of all oils were held at a F during the entire test. Some lots in bottles ...

During recent studies of oxidative phosphorylation in rat liver mitochondria (2, 3)) we observed that preparations isolated with meticulous care catalyzed a significant uptake of inorganic orthophosphate in the absence of any added substrate. Although incidental observations of endogenous activity of isolated mitochondria have been noted by others (P9), no extensive study of this phenomenon has...

background: fatty acids are the main compounds in edible oils. oil thermal stability depends on the composition of fatty acids. so, this study was conducted to investigate the effect of fatty acid composition on the oxidative stability of extra virgin olive oil during heating process.  methods: totally, eight virgin olive oil samples, including five imported oils from market place of mahabad an...

Refined sunflower oil has dissimilar shelf life compared to cold-pressed oil, which increases the use of refined and it is more abundant in diet. On other hand, production oils does not require chemical processing. Moreover, these contain significant amounts bioactive components with a beneficial health effect. Breeders are trying create new hybrids for improved oxidative characteristics. This ...