Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and...

Background: Probiotics have attracted a great attention aiming to develop natural non-toxic antioxidants, because of their role in decreasing the risk of reactive oxygen species (ROS) accumulation. Objectives: The purpose of this study was to assess the antioxidant activity of a probiotic Streptococcus salivarius ssp thermophillus (St.sa) and to evaluate its protective effect against the ...

Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...

Anti-oxidant effects of propofol (2, 6-diisopropylphenol) were evaluated agains carbon tetrachloridet CCl4 -induced oxidative stress in rat liver. 30 male rats were equally divided in to 6 groups (5 rats each). Group I (control), while Group II was given CCl4 (3 mL /Kg/day, IP). Animals of Groups III received only propofol (10 mg/Kg/day, IP). Group IV was given propofol+ CCl4. Group V was admin...

Regardless of toxicity of nanoparticles, cerium oxide nanoparticles (CeNPs) are emerging as a multi-functional agent for biomedical purposes. On the other hand, Organophosphorus pesticides, like malathion, are inevitably found in the environment. The common involving pathway CeNPs and malathion share is oxidative stress. Therefore, we conducted this study to find the possible neutralizing or sy...

selenium plays an important role in biological system due to its incorporation in glutathione peroxidases and thioredoxin reductase as prosthetic group, the pharmacological studies of synthetic organoseleno-compounds revealed these molecules to be used as antioxidants, enzyme inhibitors, neuroprotectors, antitumor, anti-infectious agents, cytokine inducers and immuno-modulators. the present stu...

different contraceptive methods are used by breastfeeding mothers. in general, these methods are classified into two major groups, hormonal and non-hormonal. a number of studies have shown that combined oral contraceptive pills may adversely affect the quality and the quantity of human milk. in other studies it has been shown that estrogen and progesterone seem to reduce the risk of cardiac and...

Human exposure to toxic metals and metalloids in the environment seldom occurs from a single pure compound. Most environmental exposure profiles are heterogeneous with co-exposure occurring coincident with multiple toxic metal species. This co-exposure to metals and metalloids in complex mixtures can result in a synergistic, additive or even depletive toxic response. The complexity of interacti...

objective(s):   zinc oxide nanoparticles (znp) are increasingly used in sunscreens, biosensors, food additives and pigments. in this study the effects of znp on liver of rats was investigated.     materials and methods: experimental groups received 5, 50 and 300 mg/kg znp respectively for 14 days. control group received only distilled water. alt, ast and alp were considered as biomarkers to ind...