In order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated. Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in differ...

The understanding of the biotransformations of insulin mimetic vanadium complexes in human blood and its transport to target cells is an essential issue in the development of more effective drugs. We present the study of the interaction of oxovanadium(iv) with human serum albumin (HSA) by electron paramagnetic resonance (EPR), circular dichroism (CD) and visible absorption spectroscopy. Metal c...

Several oxovanadium (IV) complexes of pyradoxamine (PM), pyridoxol (P), pyridoxal (PL), and glycinehydroxamate (GX) were obtained as a result of potentiometric data analysis using SUPERQUAD at I = 0.15 M NaCl and T = 25°C. Protonated, unprotonated and hydroxospecies were detected in solutions. No polymeric species of oxovanadium(IV) were found under the experimental conditions used. Differentia...

The interactions between platinum complexes and human serum albumin (HSA) play crucial roles in the distribution, metabolism, and activity of platinum-based anticancer drugs. Octahedral platinum (IV) complexes represent a significant class of anticancer agents that display molecular pharmacological properties different from cisplatin. In this study, the interaction between two Pt(IV) complexes ...

Oxovanadium(iv) complexes [VOCl(B)(2)]Cl (1-3) of phenanthroline bases (B), viz. 1,10-phenanthroline (phen in ), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq in ) and dipyrido[3,2-a:2',3'-c]phenazine (dppz in ), have been prepared, characterized and their DNA and protein binding, photo-induced DNA and protein cleavage activity and photocytotoxicity have been studied. Complex , structurally character...

The dipeptide and tripeptide analogues salicyl-L-aspartic acid (Sal-L-Asp) and salicylglycyl-L-aspartic acid (SalGly-L-Asp) were synthesized and their protonation and complex formation with V(IV)O2+ were studied in aqueous solution through the use of pH-potentiometry and spectroscopic (UV-Vis, CD and EPR) techniques. The phenolate terminus proved to be a good anchoring site to promote (i) the m...

The tridentate dibasic Schiff base anthranilic acid salicylideneimine (H 2SB) reacts with VO Cl2 in the presence of NaO Ac and imidazole (or its derivatives) to form dimeric oxovanadium (IV) com plexes of the type [V O (SB )(D )]2. These green or yellow-green compounds have a magnetic m oment of 1.4 B.M. at room temperature, and are non-electrolytes in M eOH. The compounds are characterised on ...