Inhibitors of histone deacetylases have been approved for clinical application in cancer treatment. On the other hand, histone acetyltransferase (HAT) inhibitors have been less extensively investigated for their potential use in cancer therapy. In prostate cancer, the HATs and coactivators p300 and CBP are upregulated and may induce transcription of androgen receptor (AR)-responsive genes, even...

This paper describes the rationale behind and results of five evaluation submissions to the NAILS (Neurally Augmented Image Labelling Strategies) challenge at the NTCIR-13 conference. Image triage is a timeand resourceintensive process for human labelers. Researchers have identified a potential P300-based BCI solution to alleviate the strain of manual labeling. The NAILS dataset was designed to...

The error-related negativity (ERN) is an event-related brain potential observed when subjects receive feedback indicating errors or monetary losses. Evidence suggests that the ERN is larger for unexpected negative feedback. The P300 has also been shown to be enhanced for unexpected feedback, but does not appear to be sensitive to feedback valence. The present study evaluated the role of expecta...

Neuropsychiatric pathologies, including neurodegenerative diseases and neurodevelopmental syndromes, are frequently associated with dysregulation of various essential cellular mechanisms, such as transcription, mitochondrial respiration and protein degradation. In these complex scenarios, it is difficult to pinpoint the specific molecular dysfunction that initiated the pathology or that led to ...

V interfejse mozg–komp'yuter na volne P300 (IMK-P300) vybor komand pol'zovatelya vozmozhen za schet fokusirovaniya im vnimaniya vneshnem stimule-komande i vydelenii iz EEG reakcii k etomu stimulu — v vide komponentov potencialov, svyazannyh s sobytiyami (PSS). Dlya polucheniya signala PSS stimuly neobhodimo mnogokratno povtoryat', odnako vvidu sushchestvuyushchej variativnosti latentnosti reakc...

Neuropsychological findings in obsessive-compulsive disorder (OCD) have been explained in terms of reduced cognitive shifting ability as a result of low levels of frontal inhibitory activity. This deficit could be reflected in an abnormal P300 component of the event-related potential. The improvement in cognitive processing due to pharmacological treatment would modify the P300 component, bring...

Limbic P300 potentials can be recorded within the mesial temporal lobes of patients with temporal lobe epilepsy (TLE). To delineate possible mechanisms of their generation and pathological alteration, we analysed limbic P300s in 55 TLE patients with and 29 without Ammon's horn sclerosis (AHS) and correlated their amplitudes with neuronal cell counts in 30 histopathological specimens. Limbic P30...

The P300 event-related potential was recorded from groups of young and elderly listeners in response to monaural and binaural stimulation. An oddball stimulus paradigm was used to record responses from 19 scalp locations. When listening to binaural stimuli, the young group showed midline and central P300 amplitude maxima, whereas the elderly group exhibited maximal responses in the midline and ...

The Event-Relational Potential (ERP) signals are non-stationary in nature. To extract the informative features from P300 signals, the wavelet analysis is the best analysis tool. This paper investigates development phases, merits and demerits of various existing P300 based Brain Computer Interface (BCI) system. It appraises limitations of wavelet based BCI systems and compares the various wavele...