Pengembangan kompetensi sosial emosional (KSE) anak sejak usia dini dapat diintegrasikan pada kegiatan Projek Penguatan Profil Pelajar Pancasila (P5) di Sekolah penelitian melalui pembelajaran yang berdiferensiasi. Penelitian ini bertujuan untuk mendeskripsikan penerapan sosia dalam menumbuhkan karakter positif. menggunakan jenis kualitatif deskriptif dengan tujuan memberikan deskripsi praktik ...

Pelaksanaan projek penguatan profil pelajar Pancasila (P5) dalam kurikulum merdeka bertujuan mengembangkan karakter Pancasila, sesuai nilai-nilai yang terkandung lima sila dan enam dimensi P5. Kebijakan untuk melaksanakan project besar ini berbasis pad acara berpikir tumbuh (growth mindset) bukan berfikir tetap (fixed yakni menekankan pada proses hanya hasil akhir. Salah satu kunci keberhasilan...

The myo-inositol phosphates (InsPs) are specific signalling metabolites ubiquitous in eukaryotic cells. Although Ins(1,3,4,5,6)P5 is the second most abundant member of the InsPs family, its certain biological roles are far from being elucidated, in part due to the large number of species formed by Ins(1,3,4,5,6)P5 in the presence of metal ions. In light of this, we have strived in the past to m...

The influence of highly phosphorylated inositol phosphates on the Ins(1,3,4,5)P4 3-phosphatase enriched from the soluble fraction of pig brain was tested, using [5-32P]Ins(1,3,4,5)P4 as substrate. Both Ins(1,3,4,5,6)P5 and InsP6 were very potent inhibitors of the Ins(1,3,4,5)P4 3-phosphatase. The Ki values were approximately 60 nM and approximately 3 nM for Ins(1,3,4,5,6)P5 and InsP6 respective...

Plant reoviruses are thought to replicate and assemble within cytoplasmic, nonmembranous structures called viroplasms. Here, we established continuous cell cultures of the white-backed planthopper (Sogatella furcifera Horváth) to investigate the mechanisms for the genesis and maturation of the viroplasm induced by Southern rice black-streaked dwarf virus (SRBSDV), a fijivirus in the family Reov...

2',5'-oligoadenylate synthetases (OAS) as a component of mammalian interferon-induced antiviral enzymatic system catalyze the oligomerization of cellular ATP into 2',5'-linked oligoadenylates (2-5A). Though vertebrate OASs have been characterized as 2'-nucleotidyl transferases under in vitro conditions, the natural occurrence of 2',5'-oligonucleotides other than 2-5A has never been demonstrated...

The cutaneous inflammation associated with acne vulgaris is caused by the anaerobic bacterium Propionibacterium acnes through activation of the innate immune system in the skin. Current standard treatments for acne have limitations that include adverse effects and poor efficacy in many patients, making development of a more effective therapy highly desirable. In the present study, we demonstrat...

The modulation of fitness by single mutational substitutions during environmental change is the most fundamental consequence of natural selection. The antagonistic tradeoffs of pleiotropic mutations that can be selected under changing environments therefore lie at the foundation of evolutionary biology. However, the molecular basis of fitness tradeoffs is rarely determined in terms of how these...

Particulate carriers such as polymeric micelles (PMs) and liposomes have been investigated to increase drug accumulation in tumors and reduce distribution to healthy tissues. In this study, we prepared PM and hybrid nanoparticles (HNPs) with poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-b-PMAA) for loading cisplatin, and evaluated cisplatin release, cytotoxicity, and biodistribution in...

The notion of mirror nodes, first introduced by Fomin, Grandoni and Kratsch in 2006, turned out to be a useful item for their design of an algorithm for the maximum independent set problem (MIS). Given two nodes u, v of a graph G = (V, E) with distG(u, v) = 2, u is called a mirror of v if N(v) \N(u) induces a (possibly empty) clique. In order to have a well defined term, we add that every compl...