OBJECTIVE This study was to investigate the synergistic growth inhibitory effect by combination of adenovirus mediated p53 gene transfer and cisplatin in ovarian cancer cell lines with different p53 gene mutation patterns. METHODS Three ovarian cancer cell lines, p53 deleted SKOV3, p53 mutated OVCAR-3, and PA-1 with wild-type p53 were transduced with human adenovirus vectors carrying p53 gene...

Objective(s): Resistance to medications is one of the main complications in chemotherapy of cancer. It has been shown that some multidrug resistant cancer cells indicate more sensitivity against cytotoxic effects of TNF-α compared to their parental cells. Our previous findings indicated vulnerability of the mitoxantrone-resistant breast cancer cells MCF-7/MX to cell de...

introduction: cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. the purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. methods: to induce bilateral cryptorchid model, immature mice were anesthetized and a...

Our previous studies have illustrated that CacyBP/SIP (Calcyclin-binding protein or Siah-1-interacting protein) promoted the proliferation of glioma cells. However, possible mechanism still needs to be clarified. In current study, we aimed uncover potential in regulating cell proliferation. We found decreased level p53, but not mRNA p53 mutant U251 line, whereas, wild-type U87 neither its nor r...

Murine double minute homolog 2 (MDM2) is an oncoprotein that induces p53 degradation via ubiquitin‑ligase activity. MDM4 cooperates with MDM2‑mediated degradation, directly inhibiting transcription by binding to its transactivation domain. Our previous study reported the simultaneous inhibition of MDM2 and using nutlin‑3 (an inhibitor MDM2‑p53 interaction) chimeric small interfering RNA DNA‑sub...

lipid rich carcinoma is rare in dog and women and is characterized by cells that have an abundant foamy cytoplasm. a 10 year old, mix breed female dog suffered two subcutaneous masses in ventral abdomen was referred to surgery department of veterinary hospital of ahvaz shahid chamran university. surgical excision and microscopic examination of masses were done. after grading by elston and ellis...

objective(s): this study focused on determining cytotoxic effects of copper oxide nanoparticles (cuo nps) on chronic myeloid leukemia (cml) k562 cell line in a cell-specific manner and its possible mechanism of cell death. we investigated the cytotoxicity of cuo nps against k562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). materials and methods: the toxicity w...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): This research is supported by a grant the Korea Health Technology R&D Project through Industry Development Institute (KHIDI) funded Ministry & Welfare and Basic Science Research Program Foundation (NRF) Education, Republic Korea. Background Doxorubicin an anthracycline anti...

Introduction: Cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. The purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. Methods: To induce bilateral cryptorchid model, immature mice were anesthetized and a...

PURPOSE Dendritic cells are the most potent antigen-presenting cells for initiating cellular immune responses. Dendritic cells are attractive immunoregulatory cells for cancer immunotherapy, and their efficacy has been investigated in clinical trials. The tumor suppressor gene p53 is pivotal in the regulation of apoptosis, and p53-based immunization is an attractive approach to cancer immunothe...