many studies have proved that the dietary micronutrient has an inhibitory effect against experimentally induced rat hepatocarcinogenesis. the present work is an attempt to understand combined effect of selenium (se) and vitamin d3 (vit d3) on some potential protein expression markers of carcinogenesis, such as metallothionein (mt), p53 and antioxidant levels during diethyl nitrosamine (den) ind...

Background: Progesterone receptor (PR), estrogen (ER) expression, human epidermal growth factor 2 (HER neu) amplification/ overexpression, and p53 nuclear protein accumulation are all significant prognostic biomarkers in breast cancer (BC). This work aims to assess the co-presence of overexpression with ER, PR, HER neu expression invasive BC specimens by IHC compare their various clinicopatholo...

Abstract Objectives The aim of this study is to investigate the effects radiofrequency radiation (RFR) on apoptosis, proliferation, stress response, and inflammation markers in colorectal cancer cells. Methods We tested intermittent exposure RFR at different frequencies two cell lines; HCT-116 DLD-1. Protein levels were subsequently analyzed by ELISA. Results led a decrease P53, p-P53, p-P38, p...

Introduction: In the last decade, several molecular pathways in gliomagenesis have been discovered, with each involving a unique set of alterations. IDH1 has become diagnostic tool latest 2016 WHO Classification. The tumour protein, p53, is involved IDH-mutant arm, observed astrocytoma and oligodendroglioma (grades II III), secondary glioblastoma. Meanwhile, EGFR c-erbB2/HER2 were postulated to...

The dynamic alterations in the cytoskeletal components actin and intermediate, etc. filaments are required for cell invasion migration. cytoskeleton is a highly structure that governed by delicate balance of filament formation disassembly. To controlling activities key epithelial mesenchymal transition (EMT) could be viable solution to metastasis. Bioinformatics technologies also allow research...

Protein methylation plays important roles in most, if not all, cellular processes. Lysine and arginine methyltransferases are known to regulate the function of histones and non-histone proteins through the methylation of specific sites. However, the role of the carboxyl-methyltransferase protein L-isoaspartyl methyltransferase (PIMT) in the regulation of protein functions is relatively less und...

Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response is correlated with the presence and type of mutant p53 protein expressed in th...

The tumor suppressor gene product p53 can activate and repress transcription. Both transcriptional activation and repression are thought to involve the direct interaction of p53 with the basal transcriptional machinery. Previous work has demonstrated an in vitro interaction between p53 and the TATA-binding protein that requires amino acids 20 to 57 of p53 and amino acids 220 to 271 of the TATA-...

Hemizygous TP53 gene deletion is the most important adverse risk factor in chronic lymphocytic leukemia (CLL), but its relationship with p53 protein expression is unclear. We investigated 110 CLL cases and correlated nuclear p53 protein immunoreactivity with TP53 gene deletion status and other CLL-associated genetic risk factors. Fluorescence in situ hybridization detected hemizygous TP53 delet...