Aging of the hematopoietic stem cell compartment is believed to contribute to the onset of a variety of age-dependent blood cell pathophysiologies. Mechanistic drivers of hematopoietic stem cell (HSC) aging include DNA damage accumulation and induction of tumor suppressor pathways that combine to reduce the regenerative capacity of aged HSCs. Such mechanisms do not however account for the chang...

This paper examines two stochastic methods stemming from polynomial dimensional decomposition (PDD) and polynomial chaos expansion (PCE) for solving random eigenvalue problems commonly encountered in dynamics of mechanical systems. Although the infinite series from PCE and PDD are equivalent, their truncations endow contrasting dimensional structures, creating significant differences between th...

We present an efficient model for the simulation of spatially incoherent sources based on Wiener chaos expansion (WCE) method with two orders of magnitude shorter simulation time over the brute-force model. In this model the stochastic wave propagation equation is reduced to a set of deterministic partial differential equations (PDEs) for the expansion coefficients. We further numerically solve...

AIMS The aim of the present study was to determine whether high and low fluoride concentrations in drinking water affected the early stages of tooth movement when heavy and light orthodontic forces were applied for 4 weeks. A further aim was to compare and evaluate the resulting two-dimensional (2-D) and three-dimensional (3-D) orthodontic tooth movement. METHODS The sample consisted of 96 ma...

A study of meningococcal carriage dynamics was performed with a cohort of 190 first-year students recruited from six residential halls at Nottingham University, United Kingdom. Pharyngeal swabs were obtained on four occasions between November 2008 and May 2009. Direct plating and culture on selective media were succeeded by identification and characterization of meningococci using PCR-based met...

We found a high prevalence of RET expression among our papillary carcinoma at 77% 08 of 53); p< 0.001. Interestingly, the follicular adenomas and nodular hyperplasia cases exhibited a low expression of RET of 18% (9 of 50 cases) and 22.7% 05 of 66) respectively. RET/PTC re-arrangement has been demonstrated in these lesions before 7,8. It has been postulated that these positive follicular cell r...

We present a general formulation for estimation of the region of attraction (ROA) for nonlinear systems with parametric uncertainties using a combination of the polynomial chaos expansion (PCE) theorem and the sum of squares (SOS) method. The uncertain parameters in the nonlinear system are treated as random variables with a probability distribution. First, the decomposition of the uncertain no...

In the present paper, analysis of solid cancer mortality and incidence risk after radiation exposure in the Techa River Cohort in the Southern Urals region of Russia is described. Residents along the Techa River received protracted exposure to ionizing radiation in the 1950s due to the releases of radioactive materials from the Mayak Production Association. The current follow-up through Decembe...

BACKGROUND Ceramic veneer fracture has occurred mainly at the incisal edge of the veneer because of greater stress. This study compares and evaluates the fracture resistance ceramic veneers with three different incisal preparations. MATERIALS & METHODS 15 human permanent maxillary central incisor extracted were selected which were divided into three groups of 5 each having a different Incial ...

Toxoplasma gondii is a widespread parasite of animals that causes zoonotic infections in humans. Previous studies have revealed a strongly clonal population structure in North America and Europe, while strains from South America are genetically separate and more diverse. However, the composition within North America has been questioned by recent descriptions of genetically more variable strains...