s: Pantoprazole 5-(difluoromethoxy)2-[(3,4-dimethoxypyridin-2-yl) methylsulfinyl]3H-benzoimidazole is a proton pump inhibitor belongs to group of benzimidazole . This compound inhabits gastric acid formation and there by it is very efficient for the treatment of gastric and duodenum ulcers. In aqueous media more acidic than pH 4 it suffers a practically complete decomposition within a period sh...

BACKGROUND Long-term aspirin prevents vascular events but is only modestly effective. Rivaroxaban alone or in combination with aspirin might be more effective than aspirin alone for vascular prevention in patients with stable coronary artery disease (CAD) or peripheral artery disease (PAD). Rivaroxaban as well as aspirin increase upper gastrointestinal (GI) bleeding and this might be prevented ...

two sensitive spectrophotometric methods are presented for the assay of pantoprazole sodium sesqui hydrate (pnt) in bulk drug and in formulations using n-bromosuccinimide (nbs) and two dyes, methyl orange and indigo carmine, as reagents. the methods involve the addition of a known excess of nbs to pnt  in acid medium, followed by determination of unreacted oxidant by reacting with a fixed amoun...

Stress-related mucosal damage (SRMD) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. Prophylaxis of SRMD with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. Both demonstrated to be effective in reducing clinically significant bleedings, while PPIs has shown to exert some anti ...

Stress-related mucosal damage (SRMD) is a significant cause of morbidity and mortality in critically ill patients due to the gastrointestinal blood loss. Prophylaxis of SRMD with proton pump inhibitors or histamine-2 blockers has gained widespread use in intensive care units. Both demonstrated to be effective in reducing clinically significant bleedings, while PPIs has shown to exert some anti ...

The aim of this study was to elucidate the roles of P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) in the plasma concentration, biliary excretion, and distribution to the liver, kidney, and brain of sunitinib. The pharmacokinetics of sunitinib was examined in rats treated with PSC833 (valspodar) and pantoprazole, potent inhibitors of P-gp and BCRP, respectively. T...

Gastroesophageal reflux disease (GERD) is a chronic, recurrent disease that affects nearly 19 million people in the US. The mainstay of therapy for GERD is acid suppression. Proton pump inhibitors (PPIs) are the most effective medication for both initial treatment and maintenance therapy of GERD. Pantoprazole, a first-generation PPI, was approved by the FDA in 2000 for the treatment of erosive ...