Pantothenate synthetase (EC 6.3.2.1), encoded by the panC gene, catalyzes the essential ATP-dependent condensation of D-pantoate and beta-alanine to form pantothenate in bacteria, yeast and plants. Pantothenate synthetase from Mycobacterium tuberculosis was expressed in E. coli, purified to homogeneity, and found to be a homodimer with a subunit molecular mass of 33 kDa. Initial velocity, produ...

We report a case of pantothenate kinase-associated neurodegeneration with increased regional cerebral blood flow (rCBF) in bilateral lentiform nuclei on technetium Tc-99m ethyl cysteinate dimer single-photon emission CT (ECD-SPECT). A 6-year-old boy presented with opisthotonus. T2*-weighted MR images revealed areas of marked hypointensity with a hyperintense focus in bilateral globus pallidus, ...

We present a case of an eleven-year-old boy presenting with progressive extrapyramidal signs and dementia. His imaging findings demonstrated the classic eye-of-the-tiger sign on T2W magnetic resonance imaging. He was diagnosed with pantothenate kinase-associated neurodegeneration (PKAN). This is a rare autosomal recessive inborn error of coenzyme A metabolism, caused by mutations in PANK2. This...

Although several workers have observed that the bacteriostatic effect of salicylate can be reversed by pantothenate, there is disagreement about the reaction step affected. Salicylate has been considered to inhibit synthesis of pantoate (Ivanovics, 1942), the conversion of pantoate to pantothenate (Roblin, 1949), and the utilization of pantothenate (Mcllwain, 1943; Work and Work, 1948); Ackeima...

During work on coenzyme A (CoA), a method for the liberation of pantothenic acid from the coenzyme was worked out (1). The method involves the use of a combination of two enzymes; namely, intestinal phosphatase and an enzyme extractable from acetone powder of bird liver (chicken (2), duck, or pigeon). This procedure proved the most efficient pretreatment to liberate bound vitamin under conditio...