BACKGROUND Oxidative stress plays a crucial role in the development of drug induced nephrotoxicity. The study aimed to determine the nephroprotective and ameliorative effects of Carica papaya seed extract in paracetamol-induced nephrotoxicity in rats. OBJECTIVES To carry out phytochemical screening of Carica papaya, measure serum urea, creatinine and uric acid and describe the histopathologic...

Pain due to intra- and extracapsular hip fractures is usually treated with opioid medication. Paracetamol (acetaminophen in North America) has better bioavailability when given intravenously than orally and has been successfully used in the postoperative care of orthopedic patients. However, no study has evaluated its use in the preoperative trauma patient. Our unit conducted a prospective, con...

conclusions intravenous administration of paracetamol immediately after knee arthroscopy improved postoperative pain, decreased analgesic administration, maintained stable hemodynamic parameters, had no complications related to opiates, no nausea and vomiting, and increased patient satisfaction and comfort in comparison to pca with morphine. results there was no significant difference regarding...

A simple, rapid, and specific spectrophotometric method was developed for the determination of paracetamol in pure form drug formulations. The depended on hydrolysis to p-aminophenol, which, oxidized under effect dissolved oxygen benzoquinoneimine. In alkaline medium, benzoquinoneimine reacts with Methyldopa produce a high stabile indophenol dye. absorbance measured at 580 nm, molar absorptivit...

Paracetamol is the commonest agent employed in self poisoning, however it is not clear whether adolescents possess insight into the serious complications associated with its misuse. Using a one page questionnaire, the availability, usage, and knowledge of toxicity of paracetamol among 1147 American and British adolescents was assessed. Although 90% of all students recognised that paracetamol co...

Paracetamol (PCM) is widely used as analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. This study gives the information about hepatoprotective activity of abelmoschus moschatus seed extract against paracetamol and ethanol induced hepatotoxicity. Paracetamol induce hepatotoxicity was evaluated by an increase (P<0.05) in serum AST, ALT, ...

Paracetamol is an effective analgesic but its mechanism of action is unclear. We investigated the effect of paracetamol and the analgesic adjuvant caffeine on the activity of NO synthase in mouse spinal cord and cerebellar slices in vitro, by measuring the conversion of [(3)H]arginine to [(3)H]citrulline. Paracetamol (100 microM) had no effect on NO synthase activity in cerebellum, but in the s...

The popularity of paracetamol as a drug for self poisoning has increased dramatically since the early 1980s ; nowadays almost 50% of episodes of self poisoning presenting to hospital involve the ingestion of paracetamol or paracetamol containing drugs. It is estimated that about 70 000 episodes of paracetamol self poisoning occur each year in Britain. Although serious morbidity and deaths are r...

The aim of this prospective trial was to compare the efficacy of gastric lavage, activated charcoal and ipecacuanha at limiting the absorption of paracetamol in overdose and to assess the significance of the continued absorption of paracetamol following treatment. Patients aged 16 and over who had ingested 5 gms or more of paracetamol within 4h of admission were entered into the trial. The perc...

A simple and highly sensitive spectrophotometric method for the determination of paracetamol has been developed. The employed methodology involves reaction of paracetamol with iron(III) and subsequent reaction with ferricyanide in acid medium, which yield a Prussian blue product with maximum absorption at 730 nm. Beer’s law was obeyed for the paracetamol concentration range from 0.20-3.00 g ml...