INTRODUCTION Paracetamol is the most common pharmaceutical agent implicated in toxic exposure in Singapore. This study aimed to describe the characteristics of paracetamol overdose in the adult population managed at a tertiary healthcare facility in Singapore. METHODS Medical records of adult patients hospitalised with a diagnosis of paracetamol overdose at National University Hospital, Singa...

This study was designed to evaluate the hepatoprotective and antioxidant activity of methanol extract of Lippia nodiflora (MELN) in acute experimental liver injury induced by paracetamol (750mg/kg, b.w). MELN at the doses of 200 and 400mg/kg, p.o was administered for 7 days and biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transamina...

The present study was done to investigate the therapeutic efficiency of Beta vulgaris roots ethanolic extract versus N-acetylcysteine (NAC) in overcoming experimentally induced hapatotoxicity rats by given double maximum dose Acetaminophen (N-acetyl-para-aminophenol (APAP) or paracetamol®) orally. experiment performed two parts: First part involved extraction using 90% solvent and detection mai...

the incidence of drug induced liver injury (dili) is about 1/1000 to 1/10000 among patients who receive therapeutic drug doses. drug induced hepatotoxicity is a major cause of acute and chronic liver disease. the severity of liver damage ranges from nonspecific changes in liver structure to acute liver failure, cirrhosis and liver cancer. some common agents that can cause liver injury are aceta...

This study of analgesic hepatotoxicity was conducted on rabbit divided into four equal groups (A—D). The group “A” served as control. The group “B” animals were administered acetylsalicylic acid (600 mg/Kg/day) orally,while group “C” animals received paracetamol (300 mg/Kg/day). The group “D” was given both the acetylsalicylic acid (300 mg/Kg/day) and paracetamol (150 mg/Kg/day). An autopsy was...