Background: The analgesic paracetamol causes a potentially fatal, centrilobular hepatic necrosis when taken in misuse and overdose. This research aimed to evaluate the protective effects of methanolic extract of Zataria Multiflora Boiss (Z. Multiflora) against hepatic damage induced by paracetamol-induced hepatotoxicity in male Wistar rats. Methods: for this purpose, paracetamol was administrat...

Paracetamol is the most widely used and prescribed drug word-wide. It common cause of poisoning fatality due to toxic administration throughout world. A 34-year-old female patient applied our ED with complaint swallowing 33 g paracetamol. After routine toxicity treatment, on third day hospitalization, dyspnea pain right hemithorax flank occurred. Chest X-ray showed blunted sinus. CT revealed bi...

whom she (solely) confided, who insisted that this could be dangerous and referred to the episode of Casualty, which had been screened the previous week. It was only when the friend detailed the fate of the young girl in the television series, who had taken an overdose of paracetamol and progressed to liver failure, that our patient reluctantly agreed to go to hospital. This patient had not vie...

In a regional survey of paracetamol overdose, 201 patients were admitted to hospital over 12 months. Chronic alcoholism was present in 10% of cases. Over 25% of patients were females aged 20 years or less. Initial blood paracetamol levels were in the toxic range in 16% and histologically severe liver damage eventually found in 20% of those biopsied. This finding corresponded to a serum aspartat...

Early changes in coagulation were found in patients following a paracetamol overdose. Low levels of clotting factors II, V and VII were present within 24 hours of the overdose. As the levels of factor II correlated with plasma fibrinogen values at this time, it is possible that they were consumed in the process of intravascular coagulation, although this was not supported by the presence of rai...