Using computed thermography continuous temperature recordings were made before and after cold challenge of the fingers of control subjects and patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated with systemic sclerosis. Basal skin temperature measurements (Tpre) were significantly lower in patients with primary Raynaud's phenomenon and Raynaud's phenomenon associated ...

Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequent involvement of internal organs such as lungs, gastrointestinal tract, or kidneys. Docetaxel is a chemotherapeutic agent which has been associated with cutaneous side effects. An uncommon cutaneous side effect of docetaxel is scleroderma-like skin changes that exten...

Standard electrophoresis methods were used in the qualitative and quantitative protein analyses of cerebrospinal fluid (CSF). Disc electrophoresis was carried out for detection of oligoclonal IgG bands in cerebrospinal fluid on polyacrylamide gel. Pairs of CSF and serum were taken from 30 patients, mainly with multiple sclerosis and other central nervous system dysfunctions, polyradiculoneuriti...

A clinical case of the development rapidly progressive systemic sclerosis after repeated coronavirus infection is described. The contribution occupational hazards, oncological process and radiation therapy to pathogenesis this disease discussed. Hydropericardium was a feature picture, as well rare immunological markers late onset sclerosis.

Recent approval of the anti-interleukin (IL)-6 receptor antibody tocilizumab by US Food and Drug Administration (FDA) for slowing rate decline in pulmonary function adult patients with systemic sclerosis-associated interstitial lung disease is a welcome step towards better treatment outcomes sclerosis. Systemic has emerged as one major causes death very high burden unmet need. Tocilizumab secon...

To evaluate the effect of intravenous rituximab, a monoclonal antibody to B-cells, on interstitial lung disease, skin fibrosis and arthritis in patients with systemic sclerosis (SSc).