نتایج جستجو برای: parathyroid adenoma
تعداد نتایج: 36596 فیلتر نتایج به سال:
We present a case of a parathyroid adenoma on the ipsilateral side of thyroid hemiagenesis-which, to our knowledge, is the third reported case of this entity. A 41-year-old man with nephrolithiasis was found to have elevated calcium and intact parathyroid hormone levels. Both ultrasound and technetium sestamibi scintigraphy with single photon emission computed tomography confirmed left thyroid ...
Parathyroid tumors are heterogeneous, and diagnosis is often difficult using histologic and clinical features. We have undertaken expression profiling of 53 hereditary and sporadic parathyroid tumors to better define the molecular genetics of parathyroid tumors. A class discovery approach identified three distinct groups: (1) predominantly hyperplasia cluster, (2) HRPT2/carcinoma cluster consis...
Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion. Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin and calmodulin-dependent protein kinase II (CaMKII), have well-established roles in ...
The aim of this study was to correlate the uptake of 99mTc-methoxy-isobutyl-isonitrile (MIBI) with ultra-structural features of parathyroid adenomas. Twenty patients with proven primary hyperparathyroidism were evaluated prospectively. Preoperative double-phase 99mTc-MIBI scintigraphy was performed in all patients and the degree of tracer uptake by the parathyroid lesions was assessed visually ...
Parathyroid specimens removed from patients with clinical hyperparathyroidism were cultured in a two-layer soft-agar system. Four patients had parathyroid hyperplasia and one had a parathyroid adenoma. Colonies grew from single-cell suspensions of each specimen. Plating efficiency ranged from 0.001 to 0.05%. No colonies grew from normal bovine parathyroid specimens. Parathormone was detected in...
Objective: The purpose of the present study was to evaluate the accuracy of double phase Tc sestamibi scintigraphy in the assessment of parathyroid glands in patients with hyperparathyroidism and to compare this method with the high-resolution ultrasonography. Methods: From August-1998 through August-2000, we performed Tc -MIBI scintigraphy (MIBI) and neck ultrasonography in 35 patients who wer...
BACKGROUND Atypical carcinoid arising from the mediastinal tissue is a rare neuroendocrine tumor and an association with parathyroid adenoma is very unusual. We report an unusual case of atypical carcinoid of mediastinum with metastasis in a patient presenting with parathyroid adenoma, which is the first case to be reported from Pakistan. CASE PRESENTATION A 51-year-old Pakistani man was seen...
Abstract Aim to measure the sensitivity of SPECT in localising parathyroid adenomas particularly whilst attempting minimally invasive parathyroidectomy. Method 2-cycles prospective study correlating and operative findings was conducted. All patients underwent ultrasound SPECT, those with concordant on both modalities parathyroidectomy, discordant had central neck exploration. Following findings...
OBJECTIVE To evaluate the clinical characteristics and outcome of patients with parathyroid adenoma. METHODS We diagnosed and operated 54 patients with primary hyperparathyroidism in the Faculty of Medicine, Gazi University, Turkey from January 2000 to December 2004. In this study, 52 (96.2%) of these patients who had parathyroid adenoma were retrospectively evaluated. RESULTS There were 46...
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