CKD leads to disturbances in multiple interrelated hormones that regulate bone and mineral metabolism. The renal handling of mineral metabolism hormones in humans is incompletely understood. We determined the single-pass renal clearance of parathyroid hormone, fibroblast growth factor 23, vitamin D metabolites, and phosphate from paired blood samples collected from the abdominal aorta and renal...

UNLABELLED BACKGROUND Increasing evidence suggests the bidirectional interplay between parathyroid hormone and aldosterone as an important mechanism behind the increased risk of cardiovascular damage and bone disease observed in primary hyperparathyroidism. Our primary object is to assess the efficacy of the mineralocorticoid receptor-blocker eplerenone to reduce parathyroid hormone secretio...

Human parathyroid hormone (hPTH) is a peptide hormone consisting of 84 amino acids (hPTH(l-84)). A gene coding for human parathyroid hormone (hPTH) was synthesized and cloned into REP1 expression vector. REP1 is an expression vector which has nmt1 strong promoter which is thiamine repressible. The DNA insert was designed for secretory production of Human Parathyroid hormone by linking cpy1 secr...

The striking clinical benefits of intermittent parathyroid hormone in osteoporosis have begun a new era of skeletal anabolic agents. Recombinant human parathyroid hormone (rhPTH) (1-34) is the first US Food and Drug Administration-approved anabolic therapy. Its use has been limited by the need for subcutaneous injection. Newer delivery systems include transdermal and oral preparations. Newer an...

We describe a 59-year-old woman who presented with pathological osteoporosis, cerebral infarction, hypercalcemia, and markedly high parathyroid hormone levels. The diagnosis was primary hyperparathyroidism, and parathyroidectomy was performed. Histopathological examination showed parathyroid adenoma. Surgical exploration for recurrent parathyroid carcinoma was undertaken at 2 and 3 years after ...

Background: Primary hyperparathyroidism (PHPT) results from excessive parathyroid hormone one or more overactive gland(s). An estimated 90% of PHPT cases are sporadic, and up to 10% inherited, comprising hereditary (HHPT). Genetic testing can aid in diagnosis management influence other family members.

DNA/RNA Description PTHLP is encoded by a single gene that is highly conserved among species. The gene is composed of 7 exons spanning a region of 13,899 bases (Start: 28,002,284 bp from pter; End: 28,016,183 bp from pter). Orientation: minus strand. The genomic DNA for the PTHLP gene was isolated from a human placental genomic library. Transcription The sequence is supported by 3 sequences fro...

23 Background: To evaluate the influence of parathyroid mass on the regulation of 24 parathyroid hormone (PTH) secretion, we investigated the relationship between the 25 resected parathyroid gland in total parathyroidectomy and the parathyroid hormone 26 level in hemodialysis patients with secondary hyperparathyroidism. 27 Methods: From January 2009 to July 2014, 223 patients undergoing total 2...

BACKGROUND AND OBJECTIVES Parathyroid hormone, calcium, and phosphate have been independently associated with cardiovascular event risk. Because these parameters may be on the same causal pathway and have been proposed as quality measures, an integrated approach to estimating event risks is needed. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Prevalent dialysis patients were followed from Au...