Concomitant thyroid disease is not unusual among patients with primary hyperparathyroidism. However, the simultaneous occurrence of parathyroid and thyroid carcinoma is extremely rare. We report a 38-year-old man with primary hyperparathyroidism who presented with osteitis fibrosa cystica complicated with pathologic femoral neck fracture. Preoperative investigation for exclusion of multiple end...

of an ectopic, overly-descended superior parathyroid adenoma in both primary and reoperative parathyroid surgery. Methods: A prospective analysis of consecutive patients undergoing parathyroid surgery in a tertiary endocrine surgery practice from March 2004 to April 2013 was undertaken. All patients undergoing curative primary or reoperative surgery for single-gland parathyroid adenomas were id...

A young 18-year-old female patient with general bone pain and history of multiple fractures brought her to our medical attention. Laboratory work showed hypercalcemia and high parathyroid hormone levels in the blood. Radiograph imaging revealed severe scoliosis with multiple vertebrae fractures with decreased bone mineral density. Sestamibi showed parathyroid adenoma. This case emphasizes the i...

Primary hyperparathyroidism is caused by a single parathyroid adenoma in the majority of patients. Localization of parathyroid adenomas prior to surgery has the benefit of allowing a minimally invasive approach. Over the years, multiple imaging modalities have been employed in an attempt to identify the site preoperatively, with varying degrees of success. In this study, we explore the accuracy...

BACKGROUND Intraoperative parathyroid hormone level (IOPTH) is withdrawn during parathyroidectomy to confirm the success of the procedure. Recently, the importance of IOPTH has been put to question. The purpose of this study is to determine whether IOPTH is necessary for all patients undergoing parathyroidectomy in the presence of frozen section. MATERIALS AND METHODS A cohort study of parath...

Confident localisation of ectopic parathyroid adenomas, particularly those outside the neck, can be difficult. Even preoperative radiological imaging may not be helpful, as there are few characteristic findings. We report a case in which hyperfunctioning ectopic parathyroid tissue in the mediastinum was detected with technetium-99m-sestamibi single-photon emission computed tomography and accura...

CONTEXT An international workshop on primary hyperparathyroidism (PHPT) was convened on May 13, 2008, to review and update the previous summary statement on the management of asymptomatic PHPT published in 2002. EVIDENCE ACQUISITION Electronic literature sources were systematically reviewed, addressing critical aspects of the surgical issues pertaining to the indications, imaging, surgical tr...

The clinical diagnosis of primary hyperparathyroidism is based largely on serum laboratory test results, as patients often are asymptomatic. Surgery, often with bilateral exploration of the neck, has been considered the definitive treatment for symptomatic disease. However, given that approximately 90% of cases are due to a single parathyroid adenoma, a better treatment may be the selective sur...

Incidence of primary hyperparathyroidism due to parathyroid carcinoma along with non-medullary thyroid carcinoma is extremely rare. The authors present the unique case of a patient with a 4.3 × 3.1 × 2.5 cm parathyroid carcinoma on the left side, and a 5 mm papillary thyroid microcarcinoma on the right side. The patient was operated thrice because of persistent hyperparathyroidism. The literatu...

Objectives. We compared five parathyroid scintigraphy protocols in patients with primary (pHPT) and secondary hyperparathyroidism (sHPT) and studied the interobserver agreement. The dual-tracer method ((99m)Tc-sestamibi/(123)I) was used with three acquisition techniques (parallel-hole planar, pinhole planar, and SPECT/CT). The single-tracer method ((99m)Tc-sestamibi) was used with two acquisiti...