BACKGROUND Paired associative stimulation (PAS) is widely used to induce plasticity in the human motor cortex. Although reciprocal inhibition of antagonist muscles plays a fundamental role in human movements, change in cortical circuits for reciprocal muscles by PAS is unknown. METHODS We investigated change in cortical plasticity for reciprocal muscles during PAS. PAS consisted of 200 pairs ...

Per-ARNT-Sim (PAS) domains are essential modules of many multi-domain signalling proteins that mediate protein interaction and/or sense environmental stimuli. Frequently, multiple PAS domains are present within single polypeptide chains, where their interplay is required for protein function. Although many isolated PAS domain structures have been reported over the last decades, only a few struc...

Para-aminosalicylic acid (PAS), an FDA-approved anti-tuberculosis drug, has been used successfully in the treatment of severe manganese (Mn)-induced Parkinsonism in humans [Jiang Y-M, Mo X-A, Du FQ, Fu X, Zhu X-Y, Gao H-Y, et al. Effective treatment of manganese-induced occupational Parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study. J Occup Environ Med 2006;48:644-9]. T...

Enhancements in the strength of corticospinal projections to muscles are induced in conscious humans by paired associative stimulation (PAS) to the motor cortex. Although most of the previous studies support the hypothesis that the increase of the amplitude of motor evoked potentials (MEPs) by PAS involves long-term potentiation (LTP)-like mechanism in cortical synapses, changes in spinal excit...

The basic–helix–loop–helix-PAS (bHLH–PAS) proteins comprise a prominent class of transcriptional regulators that control a variety of developmental and physiological events including neurogenesis, tracheal and salivary duct formation, toxin metabolism, circadian rhythms, response to hypoxia, and hormone receptor function. The bHLH–PAS proteins have a number of similarities with other bHLH prote...

Methods and results: Anthocyanins and PAs were analyzed by HPLC in three wine varieties during maceration time (20 days). The results showed that anthocyanin extraction followed the same kinetics for the three varieties. In the case of PAs, Syrah must-wine showed the highest concentration of these compounds, which were seen to be mainly skin-derived. Monastrell must-wine presented the lowest co...

Glycoprotein (GP) IIIb (also termed GPIV or CD36) is an integral platelet membrane protein, and has been identified as a binding site for thrombospondin, collagen, and malaria-infected erythrocytes. PAS-IV is an integral membrane protein found in lactating mammary epithelial cells and capillary endothelial cells. The N-terminal sequence of PAS-IV is nearly identical to that of GPIIIb and monosp...

In early 1956 it was demonstrated that the combination of isoniazid (INH) and para-aminosalicylic acid (PAS) provided a superior statistically significant treatment result in far-advanced and large cavitary tuberculous lesions.’ This study made a comparison between INH-PAS, streptomycin (SM) -INH, and SM-PAS (all SM was given intermittently). This year the use of high doses of INH in the treatm...