Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

the dynamic response of a transversely isotropic, linearly elastic layer bonded to the surface of a half-space of a different transversely isotropic material under arbitrary shape surface loads is considered. with the help of displacements and stresses green’s functions, an analytical formulation is presented for the determination of the displacements and stresses at any point in both surface l...

1 Principal Investigator of Horticulture and Curator, USDA Naitonal Clonal Germplasm Repository for Asimina species, Atwood Research Facility, Kentucky State University, Frankfort, KY 40601-2355. To whom reprint requests should be addressed. 2 Co-Investigator of Horticulture, Atwood Research Facility, Kentucky State University, Frankfort, KY 40601-2355 Abstract The pawpaw [Asimina triloba (L.) ...

Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions and associated disease. The arenavirus small RING finger protein called Z has been shown to be the main driving force of virus budding. The bu...