Known in over 150 species, cytoplasmic male sterility is encoded by aberrant mitochondrial genes that prevent pollen development. The RNA- or protein-level expression of most of the mitochondrial genes encoding cytoplasmic male sterility is altered in the presence of one or more nuclear genes called restorers of fertility that suppress the male-sterile phenotype. Cytoplasmic male sterility/rest...

A very low-cost portable Multichannel Analyzer (MCA) built with off-the-shelf commercial components is presented. Built around an universal microcontroller based platform for portable instruments, previously developed in our group, this intelligent portable MCA is operated by multicell Li-ion batteries and has power and memory autonomy for several hours of spectra collecting. The MCA integrates...

Differential DNA methylation defects of H19/IGF2 are associated with congenital growth disorders characterized by opposite clinical pictures. Due to structural differences between human and mouse, the mechanisms by which mutations of the H19/IGF2 Imprinting Control region (IC1) result in these diseases are undefined. To address this issue, we previously generated a mouse line carrying a humaniz...

Epigenetic programming is critical for normal development of mammalian embryos. Errors cause misexpression of genes and aberrant development (E. Li, C. Beard, and R. Jaenisch, Nature 366:362-365, 1993). Imprinted genes are important targets of epigenetic regulation, but little is known about how the epigenetic patterns are established in the parental germ lines and maintained in the embryo. Pat...

AS consistently demonstrated by confirmations of the Lyon hypothesis (LYON 1961, 1972), only one of the two X chromosomes is expressed genetically in females of eutherian mammals. Which of the two X chromosomes is to remain active is determined, apparently at random, during early embryogeny, and thereafter maintained in subsequent somatic cell lineages. In the germ line, however, both X's appea...

Given the documented association between paternal alcoholism and negative parenting behaviors, the purpose of this study was to examine longitudinally whether marital satisfaction mediates this relationship. Participants consisted of 197 families (102 without an alcoholic father, 95 with an alcoholic father) who were assessed at three time points: when children were 12, 24, and 36 months old. R...

background primary maladaptive schemas, which are the basis of high-risk behavior and psychological disorders, result from childhood experiences with significant objects, such as fathers, in different developmental phases. objectives this endeavor examined the role of the father in predicting these schemas. patients and methods a total of 345 islamic azad university students (qom branch) who we...

BACKGROUND In marine mussels of the genus Mytilus there are two mitochondrial genomes. One is transmitted through the female parent, which is the normal transmission route in animals, and the other is transmitted through the male parent which is an unusual phenomenon. In males the germ cell line is dominated by the paternal mitochondrial genome and the somatic cell line by the maternal. Researc...