BACKGROUND In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI. METHODS We did a multicentre, prospect...

Aim Hydrocortisone is used in Congenital Adrenal Hyperplasia (CAH) as a long-term replacement therapy. Accurate dosing, patient acceptability, and ease of administration the available dosage forms are vital treatment life-long. 1 Prior to introduction licensed immediate-release formulation use variety unlicensed oral hydrocortisone preparations was widespread. This project aimed explore patient...

PURPOSE Telehealth in medical oncology has expanded secondary to the COVID-19 pandemic. However, quantitative research on telehealth use shows conflicting results patient satisfaction, whereas qualitative data are sparse. Our study aimed identify factors influencing acceptability of video visits for care before and at onset expansion because METHODS Semi-structured interviews were conducted bet...

Background Virtual healthcare services are usually provided from urban centres to outpatient clinics or underserved rural areas. This study utilises virtual pharmacy as an innovative model provide a metropolitan hospital area. Aim assesses the feasibility, and patient staff acceptability of Clinical Pharmacy Service (VCPS) in tertiary ward with limited on-site clinical services. Method Pharmaci...

BACKGROUND Coronary heart disease (CHD) is the leading cause of cardiovascular mortality worldwide, yet implementation of evidence-based strategies for secondary prevention remains suboptimal. OBJECTIVE This study aimed to evaluate the feasibility, specifically the usability and acceptability, and estimate the preliminary effectiveness of a mobile health (mHealth) intervention targeting both ...

BACKGROUND Placebo-controlled surgical trials can provide important information about the efficacy of surgical interventions. However, they are ethically contentious as placebo surgery entails the risk of harms to recipients, such as pain, scarring or anaesthetic misadventure. This has led to claims that placebo-controlled surgical trials are inherently unethical. On the other hand, without pla...

Introduction The clinician's choice of treatment for gonorrhoea focuses on clinical efficacy, patient acceptability and toxicity. These criteria inevitably encompass consideration of in vitro antimicrobial sensitivities, the pharmacokinetic properties of candidate antimicrobials, anticipated compliance, cost-effectiveness, ease of administration, patient's age, pregnancy and previous adverse dr...

OBJECTIVE To compare the effectiveness of oral misoprostol with vaginal misoprostol as a cervical priming agent prior to first trimester vacuum aspiration. DESIGN Randomised study. SETTING Scottish teaching hospital. POPULATION Primigravid women at gestations up to 91 days requesting surgical abortion under the 1967 Abortion Act. METHODS Sixty-four women were randomised to receive misop...

BACKGROUND Marijuana is the most widely used illicit substance during pregnancy. Technology-delivered brief interventions and text messaging have shown promise in general and pregnant samples but have not yet been applied to marijuana use in pregnancy. OBJECTIVE The objective of the study was to evaluate, among pregnant women and prenatal care providers, the acceptability of an electronic bri...