In this chapter, we propose a service-based engineering framework to support distributed product realization. Adaptability is the key strength of this framework, which arises from an appropriate balance between ease of use of the framework and the flexibility for reconfiguration. Standardization of the interfaces between services permits communication between diverse software agents and relieve...

The objectives of this research were to determine the influence of hypobaria (reduced atmospheric pressure) and reduced partial pressure of oxygen (pO2) [hypoxia] on carbon dioxide (CO2) assimilation (C(A)), dark-period respiration (DPR) and growth of lettuce (Lactuca sativa L. cv. Buttercrunch). Lettuce plants were grown under variable total gas pressures [25 and 101 kPa (ambient)] at 6, 12 or...

Bombesin (BBN), a 14 amino acid peptide, is an analogue of human gastrin-releasing peptide (GRP) that binds to GRP receptors (GRPrs) with high affinity and specificity. The GRPr is overexpressed on a variety of human cancer cells, including prostate, breast, lung, and pancreatic cancers. The specific aim of this study was to develop Tc(I)-radiolabled BBN analogues that maintain high specificity...

Oral streptococci are primary colonizers of tooth surfaces and Streptococcus mutans is the principal causative agent of dental caries in humans. A number of proteins are involved in the formation of monospecies biofilms by S. mutans. This study analyzed the protein expression profiles of S. mutans biofilms formed in the presence or absence of S. gordonii, a pioneer colonizer of the tooth surfac...

BACKGROUND Surveillance represents a key strategy to control type 1 diabetes mellitus (T1DM). In Italy, national data are missing. This study aimed at evaluating the incidence of T1DM in subjects <18 year olds in Apulia (a large southeastern region, about 4,000,000 inhabitants) and assessing the sensitivity of the regional Registry of Childhood-Onset Diabetes (RCOD) in the 2009-2013 period. M...

This study was to investigate whether the time to the lowest postoperative CEA can predict cancer survival. We enrolled 155 rectal cancer patients in this retrospective and longitudinal cohort study. Deepness of response (DpR) of CEA refers to the relative change of the lowest postoperative CEA level from baseline, and time to DpR (TTDpR) refers to the time from surgery to the lowest postoperat...

This paper illustrates how multiple scattering signatures affect Global Precipitation Measuring (GPM) Mission Dual-Frequency Precipitation Radar (DPR) Ku and Ka band reflectivity measurements and how they are consistent with prelaunch assessments based on theoretical considerations and confirmed by airborne observations. In particular, in the presence of deep convection, certain characteristics...

Domain architectures and catalytic functions of enzymes constitute the centerpieces of a metabolic network. These types of information are formulated as a two-layered network consisting of domains, proteins, and reactions-a domain-protein-reaction (DPR) network. We propose an algorithm to reconstruct the evolutionary history of DPR networks across multiple species and categorize the mechanisms ...

The Drosophila sex determination hierarchy controls all aspects of somatic sexual differentiation, including sex-specific differences in adult morphology and behavior. To gain insight into the molecular-genetic specification of reproductive behaviors and physiology, we identified genes expressed in the adult head and central nervous system that are regulated downstream of sex-specific transcrip...

Absh-crct-The reliability of distributed processing system (DPS) can be expressed by the analysis of distributed program reliability (DPR) and distributed system reliability (DSR). One of the good approaches to formulate these reliability performance indexes is to generate all disjoint File Spanning l h e s (FST’s) in the DPS graph such that the DPR and DSR can be expressed by the probability t...