BACKGROUND Shorter manual chest compression pauses prior to defibrillation attempts is reported to improve the defibrillation success rate. Mechanical load-distributing band (LDB-) CPR enables shocks without compression pause. We studied pre-shock pause and termination of ventricular fibrillation/pulseless ventricular tachycardia 5s post-shock (TOF) and return of organized rhythm (ROOR) with LD...

COVV: I say to myself that the earth is extinguished, though never saw it lit. (Pause.) It’s easy going. When fall I’ll weep for happiness. (Pause. He goes towards door.)HAMM: Clov! (C...

Awareness of its rich structural pathways has earned the external segment of the globus pallidus (GPe) recognition as a central figure within the basal ganglia circuitry. Interestingly, GPe neurons are uniquely identified by the presence of prominent pauses interspersed among a high-frequency discharge rate of 50-80 spikes/s. These pauses have an average pause duration of 620 ms with a frequenc...

We previously analyzed the role of pausing induced by hairpin structures within RNA templates in facilitating strand transfer by HIV-1 RT (reverse transcriptase). We proposed a multistep transfer mechanism in which pause-induced RNase H cuts within the initial RNA template (donor) expose regions of cDNA. A second homologous RNA template (acceptor) can interact with the cDNA at such sites, initi...

Why such relentless phreneticism? Why, when the media consider a piece of science to be of public interest, do they invariably splash it as news for immediate consumption? Why so little insight, so few reflective or truly helpful feature articles after a pause for thought? One answer is that, along with novelty, we all need topicality (real or apparent) to attract our attention to a news story....

This document presents a streamlined approach to modeling filled pause distribution in spontaneous speech and populating a large clean corpus, making use of only the SRILM toolkit and a small training set. Although used for filled pause modeling, it can be fairly general and may be used to model other types of disfluencies, punctuation or sentence boundaries, with a minimal set of changes.

Omnidirectional pause neurons (OPNs) pause for the duration of a saccade in all directions because they are part of the neural mechanism that controls saccade duration. In the natural situation, however, large saccades are accompanied by head movements to produce rapid gaze shifts. To determine whether OPNs are part of the mechanism that controls the whole gaze shift rather than the eye saccade...

Most eukaryotic protein-coding transcripts contain introns, which vary in number and position along the transcript body. Intron removal through pre-mRNA splicing is tightly linked to transcription by RNA polymerase II as it translocates along each gene. Here, we review recent evidence that transcription and splicing are functionally coupled. We focus on how RNA polymerase II elongation rates im...

BACKGROUND: Minimizing the chest compression pause associated with application of a mechanical CPR device is a key component of optimal integration into the overall resuscitation process. As part of a multi-agency implementation project, Anchorage Fire Department deployed LUCAS CPR devices on BLS and ALS fire apparatus for initiation early in resuscitation efforts. A 2012 report identified the ...