Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have been detected in humans and wildlife. Using in vitro models, we recently showed that OH-PBDEs disrupt oxidative phosphorylation (OXPHOS), an essential process in energy metabolism. The goal of the current study was to determine the in vivo effects of OH-PBDE reported in marine wildlife. To this end, we exposed zebrafish larvae to 17 OH...

The present study investigated the human exposure to PCBs, PBDEs and HBCDs in three Vietnamese e-waste recycling sites (EWRS) using breast milk as bioindicator. The general contamination patterns followed the order of PCBs > PBDEs > HBCDs except for some recycling workers with higher levels of PBDEs than PCBs. Compared with the urban site, human exposure to PBDEs in two EWRS was significantly h...

In the Czech Republic no study on the levels of brominated flame retardants in human milk has been conducted, yet. In the first step analytical method for determination of PBDEs in this bioindicator matrix was implemented. Liquid–liquid extraction (LLE) (hexane, diethyl ether), followed by gel permeation chromatography was employed for isolation of PBDEs. Identification and quantification of PB...

Understanding Branches Out Insights into PBDE Impacts on Brain Development Polybrominated diphenyl ether (PBDE) flame retardants and their hydroxylated metabolites are structurally similar to thyroid hormone. A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormon...

Title of Thesis: ENVIRONMENTAL FATE OF POLYBROMINATED DIPHENYL ETHERS IN AGRICULTURAL SOILS WHICH HAVE RECEIVED BIOSOLIDS APPLICATION Natasha Almeida Andrade, Master of Science, 2008 Directed By: Professor Alba Torrents Department of Civil and Environmental Engineering and Dr. Laura McConnell U.S. Department of Agriculture Polybrominated diphenyl ethers (PBDEs) are used as additives in consumer...

Harbour seals (Phoca vitulina) and harbour porpoises (Phocoena phocoena) are top predators in the North Sea and consequently accumulate a variety of pollutants in their tissues. Concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and their hydroxylated metabolites (HO-PCBs and HO-PBDEs) were measured in serum of wild harbour seals (n=47) and captive harbou...

A 469 over time could have altered any observed exposure–response associations. In addition, the authors did not indicate how assessments of individual children changed over time. If different children contributed to associations at different ages, the reported findings may not be indicative of a causal role for PBDEs. Notably, most associations were found at earlier ages, suggesting that even ...

Human exposure to indoor dust enriched with endocrine-disrupting chemicals released from numerous indoor sources has been a focus of increasing concern. Longer residence times and elevated contaminant concentrations in the indoor environment may increase chances of exposure to these contaminants by 1000-fold compared to outdoor exposure. To investigate the occurrence of semi-volatile endocrine-...

Contaminants described as organochlorines (OCs; e.g., polychlorinated biphenyls [PCBs]) are present in tissues of marine mammals, including beluga whales (Delphinapterus leucas), but the complexity of contaminant exposure often is not fully known. The PCBs, OC pesticides, polybrominated diphenyl ether (PBDE) flame retardants, methylsulfonyl (MeSO2)- and hydroxy (OH)-PCB metabolites, and OH-PBDE...

The aim of this study was to quantify the amount of polybrominated diphenyl ethers (PBDEs) released into the environment (biosolids, effluent) from a conventional Australian activated sludge treatment wastewater treatment plant (WWTP). The concentration of PBDE congeners was measured at various treatment stages and included four aqueous samples (raw, primary, secondary and tertiary effluents) a...