PURPOSE To investigate the differential expression of the glycoprotein clusterin/apoJ (CLU) in normal and Fuchs' endothelial dystrophy (FED) corneal endothelium and to compare the expression of various forms of CLU in normal and FED tissue. METHODS FED and pseudophakic bullous keratopathy (PBK) corneal buttons were removed during transplantation, and normal corneas were obtained from tissue b...

Ubiquitin ligases (E3s) confer specificity to ubiquitination by recognizing target substrates. However, the substrates of most E3s have not been extensively discovered, and new methods are needed to efficiently and comprehensively identify these substrates. Mostly, E3s specifically recognize substrates via their protein interaction domains. We developed a novel integrated strategy to identify s...

Ochrobactrum anthropi, formerly known as CDC group Vd, is an oxidase-producing, gram-negative, obligately aerobic, non-lactose-fermenting bacillus of low virulence that occasionally causes human infections. It is highly resistant to all b-lactams except imipenem. A clinical isolate, SLO74, and six reference strains were tested. MICs of penicillins, aztreonam, and most cephalosporins tested, inc...

PURPOSE To evaluate anterior segment modifications after penetrating keratoplasty (PKP), previous anterior chamber intraocular lens (IOL) removal, and Verisyse IOL (AMO) implantation over the iris or under the iris for the treatment of pseudophakic bullous keratopathy (PBK) using ultrasound biomicroscopy. SETTING Department of Ophthalmology, Poitiers University Hospital, Poitiers, France. M...

OBJECTIVES To examine the variables affecting outcomes for sequential bilateral cochlear implantation patients in the adolescent population. STUDY DESIGN Retrospective chart review at tertiary care center. METHODS Main outcome measures were open set speech recognition tests at the word (Consonant-Nucleus-Consonant/Phonetically Balanced Kindergarten List Test [CNC/PBK]) and sentence levels i...

Tebufenpyrad is a pesticide active substance used as insecticide, for which the mechanism of action an inhibition Complex I Mitochondrial Electron Transport Chain (ETC). In vitro experimental data demonstrated that Tebufenpyrad-induced ETC's complex leads to oxidative damage, reduction oxygen consumption rates with increasing in mitochondrial stress level and dysfunction dopaminergic neuronal c...

In comparison to liver toxicology, little is known about mechanisms of adverse effects in the kidney and only limited computational models exist investigate nephrotoxicity. However, a major target for toxicity by pharmaceuticals environmental pollutants. Accumulation play an important role certain nephrotoxicity pathways. Therefore, physiologically-based kinetic (PBK) mechanistic are considered...

Victor B. Amoroso, Fulgent P. Coritico, Yvonne Love L. Carino, and Peter W. Fritsch. 2020. Lycophytes Ferns of Mt. Hamiguitan Range Wildlife Sanctuary. (ISBN-13: 978-621-8226-00-5. pbk). Central Mindanao University Press, Town, Musuan, 8710 Buikidnon, Philippines. (Orders: https://www.cmu.edu.ph/home/production/rgmo/instructional-materials-development-center-imdc/). Price not given, 166 pp., ma...