Bone is the most common site of metastasis in prostate cancer (PC), and to generate an animal model to investigate the basis of the unique organ tropism of PC cells for bone, we engrafted humanized non-obese diabetic/severe combined immunodeficient (NOD/SCID-hu) mice with human adult bone (HAB) and lung (HAL). Human PC cell lines LNCaP (1 x 10(7)) and PC-3 (5 x 10(6)) were injected into male NO...

Ischemic preconditioning (PC) induces delayed phase of protection, known as the second window of protection (SWOP). We investigated this phenomenon in rat and correlated it with the expression of 72-kDa heat shock protein (HSP 72). Rats were preconditioned with 1, 2, and 3 cycles of 5-min left anterior descending artery occlusions, each separated by a 10-min reperfusion (PC × 1, PC × 2 and PC ×...

The 52-aminoacid peptide adrenomedullin (AM) is expressed in the normal and malignant prostate. We have previously shown that prostate cancer cells produce and secrete AM, which acts as an autocrine growth inhibitory factor. We have evaluated in the present study the role of AM in prostate cancer cell apoptosis, induced either by serum deprivation or treatment with the chemotherapeutic agent et...

BACKGROUND Parallel imaging by sensitivity encoding (SENSE) may considerably reduce scan time in MRI. For rapid flow quantification in children with congenital heart disease, we evaluated phase-contrast MRI (PC-MRI) techniques combined with SENSE. METHODS AND RESULTS In 22 pediatric patients (mean age, 7.2+/-6.2 years) with cardiac left-to-right shunt, blood flow rate in the pulmonary artery ...

Background—Parallel imaging by sensitivity encoding (SENSE) may considerably reduce scan time in MRI. For rapid flow quantification in children with congenital heart disease, we evaluated phase-contrast MRI (PC-MRI) techniques combined with SENSE. Methods and Results—In 22 pediatric patients (mean age, 7.2 6.2 years) with cardiac left-to-right shunt, blood flow rate in the pulmonary artery (Qp)...

Pancreatic cancer (PC) is one of the deadliest solid malignancies carrying a gloomy 5-year survival rate less than 5%. The signal transducer and activator of transcription 3 (STAT3) is a common transcriptional regulator, whose aberrant expression has been widely found in human cancers, including PC. Our current study aimed to illustrate the roles of common variants, in the three prime untransla...

Our previous results indicated that both the secreted and the intracellular form of full length and 1-97 N-terminal fragment of IGFBP-3 induces apoptosis in PC-3 human prostate cancer cells in an IGF-dependent and independent manner. This study was undertaken to delineate possible down-stream signaling pathways that are involved in this process. Intact IGFBP-3 and its N-terminal 1-97 fragments ...

Objective: For Gleason Score (GS) 3+3:6 prostate cancer (PC) cases, recent guidelines recommend clinical follow-up instead of radical treatment due to complications. One the most important disadvantages is that low-grade PC may include local aggressive behavior. Hence, our aim here was investigate incidence extraprostatic extension (EPE), a behavior, in GS6 cases. Material and Methods: We exami...

Let Pc(x)={p?x|p,[pc]areprimes},c?R+?N and ?sym2f(n) be the n-th Fourier coefficient associated with symmetric square L-function L(s,sym2f). For any A>0, we prove that mean value of over Pc(x) is ?xlog?A?2x for almost all c??,(5+3)/8?? in sense Lebesgue measure. Furthermore, it holds c?(0,1) under Riemann Hypothesis. obtain asymptotic formula ?f2(n) ?p,qprimep?x,q=[pc]?f2(p)=xclog2x(1+o(1)),...

introduction: langerhans cell histiocytosis (lch) is a rare disease characterized by clonal prolifera-tion of histiocytosis in different tissues. permanent consequences (pc) described among subjects with langerhans cell histiocytosis (lch).in this study we report the prevalence of permanent sequel among long – term survivors of lch in our center. methods: we had 30 cases of lch from 1989 – 2001...