Abstract Multifunctional fiber mats are explored as potential bioactive matrices for the development of next generation guided bone regeneration membranes with tunable microstructure, strength and therapeutic activity. In present study, polycaprolactone (PCL) nanofibers different concentrations ascorbic acid derivatives (ascorbyl palmitate) strontium polyphosphate nanoparticles (Sr-polyP NPs) w...

Aim: The regeneration of small periodontal defects has been considered an important divide and challenging issue for dental practitioners. aim this preliminary in vitro study was to analyze the effects polycaprolactone (PCL) nanofibers enriched with hyaluronic acid vitamin E vs. nude on gingival fibroblasts activity, innovative graft soft tissue purposes. Methods: Nanofibers were produced PCL (...

Bone extracellular matrix (ECM) is composed of mineralized collagen fibrils which support biological apatite nucleation that participates in bone outstanding properties. Understanding and mimicking bone morphological and physiological parameters at a biological scale is a major challenge in tissue engineering scaffolding. Using emergent (nano)technologies scaffold designing may be critically im...

In vitro cell culture is traditionally performed within two-dimensional (2D) environments, providing a quick and cheap way to study cell properties in a laboratory. However, 2D systems differ from the in vivo environment and may not mimic the physiological cell behavior realistically. For instance, 2D culture models are thought to induce cancer stem cells (CSCs) differentiation, a rare cancer c...

In this study, needleless electrospinning technology was used to obtain flexirubin (F)-loaded polyvinyl alcohol (PVA)_kefiran (KF)/polycaprolactone (PCL) electrospun nanofibers. The SEM images of PVA_KF_ F and PCL_F nanofibers displayed beadless morphology with average diameters 211.90 ± 96.08 1610.71 996.68 nm, respectively. FTIR-ATR analysis revealed increased intensity at specific wavelength...

The study aimed to fabricate and characterize a 2-part artificial cornea as a substitute for penetrating keratoplasty in patients with corneal blindness. The peripheral part of the artificial cornea consisted of plasma-treated electrospun poly (ɛ-caprolactone) (PCL) nanofibers, which were attached to a hydrogel disc of polyvinyl alcohol (PVA) as a central optical part. The physical properties o...

Electrospun hybrid nanofibers prepared using combinations of natural and synthetic polymers have been widely investigated in cardiovascular tissue engineering. In this study, electrospun gelatin/polycaprolactone (PCL) and collagen/poly(l-lactic acid-co-ε-caprolactone) (PLCL) scaffolds were successfully produced. Scanning electron micrographs showed that fibers of both membranes were smooth and ...

The nervous system is an important regulator of the human body because it adapts our responses to the external environment and provides people the ability of thought, memory, and emotion. PC12 is a cell line that is commonly used to study the behavior of neural differentiation. PC12 cells further differentiate into nerve cells when stimulated by nerve growth factor (NGF), which have neurite, de...