نتایج جستجو برای: pd l2

تعداد نتایج: 79105  

Journal: :Proceedings of the National Academy of Sciences 2003

Journal: :Molecular cancer therapeutics 2017
Elena Burova Aynur Hermann Janelle Waite Terra Potocky Venus Lai Seongwon Hong Matt Liu Omaira Allbritton Amy Woodruff Qi Wu Amanda D'Orvilliers Elena Garnova Ashique Rafique William Poueymirou Joel Martin Tammy Huang Dimitris Skokos Joel Kantrowitz Jon Popke Markus Mohrs Douglas MacDonald Ella Ioffe William Olson Israel Lowy Andrew Murphy Gavin Thurston

The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on antigen-presenting cells and cancer cells, resulting in suppression of T-cell effector function and tumor immune evasion. Clinical antibodies blocking the interaction between PD-1 and PD-L1 restore the cytotoxic function of tumor antigen-spe...

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