OBJECTIVE To assess the diagnostic accuracy of photodynamic diagnostic (PDD) ureterorenoscopy for detecting upper-urinary tract transitional cell carcinoma (UUT-TCC) in our initial 3 years, and compare the results with that of white light ureterorenoscopy (WLU). PATIENTS AND METHODS Between August 2007 and March 2010, 32 patients underwent PDD flexible ureterorenoscopy for UUT-TCC. Oral 5-ami...

INTRODUCTION Bladder cancer (BC) is a serious medical problem. The high rate of recurrence and progression demands the development of new methods, such as genetic markers, which allow diagnosis and patient follow-up. OBJECTIVES The aim of this study was to compare expression of HIF-1, GLUT1, endoglin, and BRIC5 in patients without and those with BC. The second group was divided into sub-group...

Stem cells display a fundamentally different mechanism of proliferation control when compared to somatic cells. Uncovering these mechanisms would maximize the impact in drug discovery with a higher translational applicability. The unbiased approach used in phenotype-based drug discovery (PDD) programs can offer a unique opportunity to identify such novel biological phenomenon. Here, we describe...

OBJECTIVE To investigate if, and in what ways, communication impairments are present in toddlers (17-37 months) diagnosed with autism and Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS). METHODS Study 1-The scores of 20 toddlers with autism or PDD-NOS (i.e. ASD group) were compared to those of 20 typically-developing infants on the Communication sub-scale of the Baby and In...

Parkinson's disease (PD) is a movement disorder and is associated with some of the intellectual disabilities like cognitive dysfunctions. PD associated cognitive dysfunctions have been proved well in both preclinical and clinical set ups. Like other neurodegenerative diseases, insults to mitochondria have a significant role in the pathobiology of PD associated dementia (PDD). Neurotoxins like M...

AIM To determine the relation between perceived driving disability and vision screening tests. METHODS 93 subjects, aged 50 years and over, with binocular visual acuity of at least 20/80. Perceived driving disability (PDD) was assessed by a questionnaire. Subtracting daytime from night-time driving question scores revealed PDD at night (PDDN), subtracting scores of questions for driving in fa...

Abstract Objective To determine whether or not distinct neuropsychological profiles could be created to aid in earlier detection Dementia with Lewy Bodies (DLB) and Parkinson’s Disease (PDD). Data Selection A literature review was conducted informally search for articles pertaining testing individuals DLB PDD that were dated within the past fifteen years. Synthesis Results indicated typically h...

24 Avian bornaviruses (ABV), representing a new genus within the family Bornaviridae, were 25 recently discovered in parrots with proventricular dilatation disease (PDD) from North 26 America and Israel. We show here that closely related viruses are also present in captive 27 European parrots of various species with PDD. The six ABV strains that we identified in 28 clinically diseased birds are...

OBJECTIVES The aim of this study was to assess the test performance and clinical effectiveness of photodynamic diagnosis (PDD) compared with white light cystoscopy (WLC) in people suspected of new or recurrent bladder cancer. METHODS A systematic review was conducted of randomized controlled trials (RCTs), nonrandomized comparative studies, or diagnostic cross-sectional studies comparing PDD ...

BACKGROUND Apolipoprotein E gene (APOE) polymorphism is an important determinant for the development of various cardiovascular and neurodegenerative disorders. There have been conflicting reports of association of APOE polymorphism with dementia in Parkinson disease (PD). OBJECTIVE To determine the relationship between APOE polymorphisms and plasma cholesterol concentration, and PD with demen...