Investigators from Soochow University, Suzhou, China, studied the possible pathogenetic mechanisms and treatment of posterior reversible encephalopathy syndrome (PRES) observed in 11 cases of pediatric acute lymphoblastic leukemia (ALL) after induction chemotherapy.

Aim: is to assess the impact of counseling on quality life (QoL) and treatment adherence. Research designs: A quasi experimental research design. Settings: The study was conducted at pediatric unit in National Cancer Institute affiliated Cairo University. Subjects: purposeful sample included (30) children newly diagnosed with “Acute Lymphoblastic Leukemia” initial diagnosis period received chem...

At the time of writing, five anti-CD19 CAR T-cell products are approved by U.S. Food and Drug Administration for seven different indications in lymphoid malignancies, including B-cell non-Hodgkin lymphoma, pediatric acute lymphoblastic leukemia, multiple myeloma. T cells chronic lymphocytic myeloid less common malignancies such as lymphomas Hodgkin lymphoma being tested early-phase clinical tri...

BACKGROUND The translocation t(1;19)(q23;p13), which results in the TCF3-PBX1 chimeric gene, is one of the most frequent rearrangements observed in B cell acute lymphoblastic leukemia. It appears in both adult and pediatric patients with B cell acute lymphoblastic leukemia at an overall frequency of 3 to 5%. Most cases of pre-B cell acute lymphoblastic leukemia carrying the translocation t(1;19...

BACKGROUND The t(9;22) and t(4;11) chromosomal translocations, which generate the BCR-ABL and MLL-AF4 fusion genes, define high-risk subtypes of acute lymphoblastic leukemia in adults. However, the prognostic impact of other rarer fusion genes is less well established in adult acute lymphoblastic leukemia than in the childhood form. DESIGN AND METHODS In the context of the German Multicenter ...

We report on posttransplant relapsed pediatric patients with B-precursor acute lymphoblastic leukemia with no further standard of care therapy who were treated with the T-cell engaging CD19/CD3-bispecific single-chain antibody construct blinatumomab on a compassionate use basis. Blast load was assessed prior to, during and after blinatumomab cycle using flow cytometry to detect minimal residual...

Despite remarkable improvement in treatment outcomes in pediatric leukemia over the past several decades, the prognosis for high-risk groups of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), as well as for relapsed leukemia, remains poor. Intensification of chemotherapy regimens for those at highest risk has improved success rates, but at the cost of significantly increase...

unilateral malignant pleural effusion as an initial manifestation that leads to the diagnosis of an underlying acute lymphoblastic leukemia is a rare event. early and accurate diagnosis of this case is important for prompt and adequate therapy. we present the case of an18-year-old male who presented to the emergency department with severe respiratory distress. chest x-ray revealed a unilateral ...