Abstract Objective Neuropsychological testing is often recommended for pediatric brain tumor survivors, yet little known about perceptions of and resources. The purpose this study to examine survivor caregiver neuropsychology resources identify factors associated with receipt neuropsychological testing. Method Survivors their families (N = 55) completed questionnaires on demographics family fun...

In this issue of Blood, Ness et al report that, despite the omission of prophylactic cranial radiotherapy (CRT) in the treatment of acute lymphoblastic leukemia (ALL), adult survivors of childhood ALL remain at risk for impaired fitness, body composition, and energy balance.

OBJECTIVES An observational cohort study was conducted in infants less than 6 weeks of age undergoing intracardiac surgery to examine the predictive value of serial postoperative lactate determination on survival and early childhood neurodevelopment. METHODS A total of 85 infants with congenital heart disease underwent intracardiac surgery between 1996 and 1999. Differences in serial lactate ...

Neurocognitive disorders are a common long-term effect in brain tumor survivors. The rate of intelligence quotient (IQ) decline is associated with a several risk factors, including tumor location, younger age at time of treatment, treatment intensity, in particular use of radiotherapy and radiotherapy dose, as well as clinical variables such as hydrocephalus and presence of epilepsy. Demyeliniz...

OBJECTIVE To evaluate the long-term effects of septic shock on cardiac function in children treated with inotropic and/or vasoconstrictive agents for 24 hours or longer. DESIGN Cohort study. SETTING Tertiary pediatric intensive care unit and outpatient follow-up clinic. PARTICIPANTS One hundred eight of 144 eligible children who were admitted to our tertiary pediatric intensive care unit ...

OBJECTIVES Physiologic dead space is associated with mortality in acute respiratory distress syndrome, but its measurement is cumbersome. Alveolar dead space fraction relies on the difference between arterial and end-tidal carbon dioxide (alveolar dead space fraction = (PaCO2 - PetCO2) / PaCO2). We aimed to assess the relationship between alveolar dead space fraction and mortality in a cohort o...

OBJECTIVES Describe the use of extracorporeal cardiopulmonary resuscitation as rescue therapy in pediatric patients who experience cardiopulmonary arrest refractory to conventional resuscitation. We report on outcomes and factors associated with survival in children treated with extracorporeal cardiopulmonary resuscitation during cardiopulmonary arrest from the American Heart Association Nation...

BACKGROUND The survival rate to discharge after a cardiac arrest in a patient in the pediatric intensive care unit is reported to be as low as 7%. The survival rates and markers for survival strictly regarding infants with cardiac arrest after congenital heart surgery are unknown. METHODS AND RESULTS Infants in our pediatric cardiac intensive care unit database were identified who had a posto...