نتایج جستجو برای: pediatric aml and prognosis
تعداد نتایج: 16873517 فیلتر نتایج به سال:
BACKGROUND Since 1983 four consecutive unified regimens: acute myeloid leukemia-Polish pediatric leukemia/lymphoma study group (AML-PPLLSG) 83, AML-PPLLSG 94, AML-PPLLSG 98 and AML-BFM 2004 Interim, for AML have been conducted by the Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG). In this paper, we review four successive studies on the basis of acute myeloid leukemia-Berlin-Frankfurt-M...
The epidermal growth factor receptor (EGFR) inhibitor erlotinib has been shown to induce complete remission of acute myeloid leukemia (AML) in two patients with concurrent lung cancer and raised attention for a role of EGFR in AML whereas a recent phase II clinical study with gefitinib in AML demonstrated a negative result on the outcome. However, from several studies, EGFR expression in AML is...
Background: Acute Myeloid Lymphoma is the clonal proliferation of non-lymphoid blasts comprising at least 20% total nucleated cells either in bone marrow or peripheral blood. In recent years, flow cytometry has emerged as a powerful diagnostic tool for AML due to its impact on treatment and prognosis.
 Aims & Objectives:
 
 To analyse findings patients diagnosed acute myeloid...
Acute megakaryoblastic leukemia(AML-M7) is a rare type of pediatric AML. It represents approximately 1% of all leukemias during childhood & has an incidence of 0.5% per million per year. In young children with Down syndrome, AML-M7 is the most common type of AML. There is no association reported till date in between Down syndrome & Haemoglobin E-Beta thalassaemia. In our case we got rare associ...
The Flt3 gene encodes a tyrosine kinase receptor that regulates proliferation and differentiation of hematopoietic stem cells. An internal tandem duplication of the Flt3 gene (Flt3/ITD) has been reported in acute myelogenous leukemia (AML) and may be associated with poor prognosis. We analyzed diagnostic bone marrow specimens from 91 pediatric patients with AML treated on Children's Cancer Grou...
Abstract This translational study aimed at gaining insight into the effects of lenalidomide in acute myeloid leukemia (AML). Forty-one AML patients aged 66 or older Swiss cohort HOVON-103 AML/SAKK30/10 were included. After randomization, they received standard induction chemotherapy with without lenalidomide. Bone marrow biopsies diagnosis and before 2nd cycle obtained to assess therapeutic imp...
Children with Down syndrome (DS) have an increased risk for leukemia. The prognosis for DS acute myeloid leukemia (AML) is better than for non-DS AML, but the clinical outcome of DS acute lymphoblastic leukemia (ALL) is equal to that of non-DS ALL. Differences in prognosis may reflect differences in cellular drug resistance. In vitro drug resistance profiles were successfully investigated on le...
Relapsed/refractory acute myeloid leukemia (R/R-AML) is characterized by a high incidence, short survival and poor prognosis. Presently, no unified effective reinduction chemotherapy regimen has been developed. Therefore, the use of regimens before allogeneic hematopoietic stem cell transplantation (allo-HSCT) controversial. Our study aims to analyze prognostic factors R/R-AML evaluate efficacy...
BACKGROUND Recent reports have indicated that microRNAs (miRNAs) play a critical role in malignancies, and regulations in the progress of adult leukemia. The role of miRNAs in pediatric leukemia still needs to be established. The purpose of this study was to investigate the aberrantly expressed miRNAs in pediatric acute leukemia and demonstrate miRNA patterns that are pediatric-specific and pro...
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