During the last 5 years massive chemotherapy and autologous bone marrow transplantation have been increasingly explored in the treatment of pediatric solid tumors, mainly for neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, Wilms' tumor, germ cell tumors, osteosarcoma, and retinoblastoma. Although the disease course could be changed successfully in most instances, the long-term survival has no...

Many cancers that present in children and adolescents are curable with surgery, chemotherapy, and/or radiation therapy. Potential adverse consequences of treatment include sterility, infertility, or subfertility as a result of either gonad removal or damage to germ cells from adjuvant therapy. In recent years, treatment of solid tumors and hematologic malignancies has been modified in an attemp...

A three-month-old female infant presented with abdominal distention for 2 months. A large palpable mass in right upper quadrant was noted on physical exam. Abdominal ultrasound revealed a large heterogeneous mass with multiple cystic components. Mass was surgically excised and pathology was consistent with mature adrenal teratoma. Teratoma is a germ cell tumor mainly found in gonadal tissues. O...

Introduction: Teratomas are non-malignantgerm cell tumors commonly composed of cell types derived from all of the three germ layers. Intracerebral teratomas typically are midline or paraxial lesions located in the pituitary stalk or the pineal region. We report our experience with mature teratomas of the posterior fossa. Case report: We present the case of an 11-yearold caucasian female with pr...

the increasing incidence of systemic candidiasis, which parallels the use of invasive and immunosuppressive medical procedures, necessitates development of rapid and cost effective tests for diagnosis of systemic candidiasis. therefore in this study 85 mice were first immunosuppressed by cyclophosphamide and then infected by candida albicans ncpf 3153. other 85 mice were employed as control. th...

Aim: This study reports surgical treatment and its outcome for boys with a testicular tumor, in order to analyze the considerations of testis-sparing surgery (TSS) investigate whether, retrospect, was according recently developed algorithm. Methods: We retrospectively reviewed tumors who underwent between January 2000 June 2020 at Wilhelmina’s Children’s Hospital Princess Máxima Center Pediatri...

[This corrects the article on p. 1657 in vol. 9, PMID: 27051301.].

Fungal brain abscess is a rare entity especially in an immune competent host. Here we report a rare case of Candida brain abscess in a 19 year old immune competent patient. The diagnosis was made by CT scan of brain and confirmed by microbiological culture. The patient did not respond to surgical intervention and antimicrobial therapy and succumbed to his illness.

OBJECTIVE To discriminate seizures from interictal dynamics based on multivariate synchrony measures, and to identify dynamics of a pre-seizure state. METHODS A linear discriminator was constructed from two different measures of synchronization: cross-correlation and phase synchronization. We applied this discriminator to a sequence of seizures recorded from the intracranial EEG of a patient ...