نتایج جستجو برای: pedigree errors
تعداد نتایج: 147734 فیلتر نتایج به سال:
In an effort to accelerate likelihood computations on pedigrees, Lange and Goradia defined a genotype-elimination algorithm that aims to identify those genotypes that need not be considered during the likelihood computation. For pedigrees without loops, they showed that their algorithm was optimal, in the sense that it identified all genotypes that lead to a Mendelian inconsistency. Their algor...
The analysis of whole-genome or exome sequencing data from trios and pedigrees has been successfully applied to the identification of disease-causing mutations. However, most methods used to identify and genotype genetic variants from next-generation sequencing data ignore the relationships between samples, resulting in significant Mendelian errors, false positives and negatives. Here we presen...
Driven by the international HapMap project, the haplotype inference problem has become an important topic in the computational biology community. In this paper, we study how to efficiently infer haplotypes from genotypes of related individuals as given by a pedigree. Our assumption is that the input pedigree data may contain de novo mutations and missing alleles but is free of genotyping errors...
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