نتایج جستجو برای: peginterferon alfa
تعداد نتایج: 19203 فیلتر نتایج به سال:
I their meta-analysis of the efficacy of peginterferon alfa-2a (PEG-IFN-α2a) or alfa2b (PEG-IFN-α2b) and ribavirin for the treatment of hepatitis C virus (HCV), Alavian et al. (1), analyzing pooled data from 7 studies, conclude that PEG-IFNα2a (with similar safety) is more effective than PEGIFN-α2b. While PEG-IFN alfa-2b with ribavirin is generally considered as the treatment of choice for chro...
UNLABELLED Treatment of chronic hepatitis C with pegylated interferon (peginterferon) and ribavirin can cause or exacerbate depression but its effects on cognitive function are largely unknown. The aim of this study was to determine whether treatment with peginterferon and ribavirin adversely impacts cognitive function in patients with chronic hepatitis C. Prior nonresponders to interferon were...
BACKGROUND Current therapy for chronic hepatitis C virus (HCV) infection is effective in less than 50% of patients infected with HCV genotype 1. Telaprevir, a protease inhibitor specific to the HCV nonstructural 3/4A serine protease, rapidly reduced HCV RNA levels in early studies. METHODS We randomly assigned patients infected with HCV genotype 1 to one of three telaprevir groups or to the c...
The impact of ribavirin (RBV) dosage on sustained virologic response (SVR) rates remains elusive in hepatitis C virus genotype 2 (HCV-2) rapid responders receiving 16 weeks of peginterferon (Peg-IFN) plus RBV. Treatment-naïve HCV-2 patients with rapid virologic response (RVR) received Peg-IFN alfa-2a 180 μg/week plus weight-based RBV (1,000 or 1,200 mg/day; cut-off body weight: 75 kg) for 6 wee...
In 1989, scientists at Chiron (acquired by Novartis in 2006), in collaboration with a CDC researcher, first reported the molecular cloning of hepatitis C virus (HCV) genome from serum samples of patients diagnosed with Non-A Non-B viral hepatitis [1]. After the discovery of HCV, tremendous progress has been made toward better understanding the virus itself and its associated chronic hepatitis C...
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