The structure-activity relationships within a series of penicillins and cephalosporins containing an N(4)-substituted piperazine-2,3-dione moiety in the C(6)/C(7)-beta-side chain are discussed.

A large volume of data on variations in serum penicillin levels has been obtained from work carried out with depot preparations of procaine benzyl penicillin in oil (to be published). Figure 1 shows frequency histograms of blood levels obtained in humans 24 hours after a single fixed dose of the same preparation. Large groups of individuals were involved and there was an interesting difference ...

• Computational/experimental approaches to the binding of lysozyme with penicillins. Predominance aromatic hydrophobic van der Waals interactions like π-π stacking. Both penicillins induce long-distance allosteric signal propagation. Results reinforce need approach these systems from both atomic and macroscopic points view. In this study we present an in-depth detailed analysis process between ...