Oxidative stress is an imbalance between the production of free radicals and antioxidant defense mechanisms, potentially leading to tissue damage. Oxidative stress has a key role in the development of cerebrovascular and/or neurodegenerative diseases. This phenomenon is mainly mediated by an enhanced superoxide production by the vascular endothelium with its consequent dysfunction. Thioctic, a...

Core-crosslinked micelles (CCMs) with a permanently charged anionic shell of sodium poly(styrene sulfonate) (PSS – Na + ) chains have been developed by convergent three-step one-pot RAFT polymerization starting 4-cyano-4-thiothiopropylsulfanyl pentanoic acid (CTPPA, R 0 -SC(S)S n Pr) as chain transfer agent, which includes polymerization-induced self-assembly (PISA) in the second step. The fina...

Datura innoxia is an important species of Solanaceae family with several purposes in folk medicine. This study intends to explore the cytotoxic effect D. on various cancer cell proliferation. ethanolic extract’s progression cycle and induction apoptosis were investigated by flow cytometry. Further, real-time PCR was employed confirm initiation. In addition, active phytochemicals identified gas ...

F atty a cid s ynthase ( FAS) inhibition initiates selective ap optosis o f can cer cel ls b oth in vivo and in vitro, which m ay i nvolve malonyl-CoA metabolism. T hese findings l ed to exploration of malonyl-CoA decarboxylase ( MCD) as a p otential novel target for cancer treatment. M CD regulates the levels of cellular malonyl-CoA through the decarboxylation of malonyl-CoA to acetyl-CoA. Mal...

Optical sensors based on surface plasmon resonance (SPR) have made great strides in the detection of various chemical and biological analytes. A is a bound, non-radiative evanescent wave generated as resonant electrons metal–dielectric to absorb energy from an incident light. As analytes bind functionalized metal substrate, refractometric response can be used for quantitation with selectivity, ...

Rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus or the entorhinal cortex were submitted to either a one-trial inhibitory avoidance task, or to 5 min of habituation to an open field. Immediately after training, they received intrahippocampal or intraentorhinal 0.5-microl infusions of saline, of a vehicle (2% dimethylsulfoxide in saline), of the glutamatergic ...

Although organic, lipophilic acids, such as acetic, propionic, sorbic and benzoic, have a long history as preservatives in the food industry, relatively high concentrations are required and their bioactivities generally pertain to retarding microbial growth rather than eliminating pathogens. Moreover, exclusive use of organic acids such as lactic or citric acid, alone, as broad-spectrum biocide...

PURPOSE As novel therapeutic agents relevant to colon cancer therapy are explored continuously, we tested 4 R2edda-type ligand precursors O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid (L1.2HCl-L4.2HCl) and corresponding palladium(II) and platinum(II) complexes against the human colon cancer cell lines CaCo-2, SW480 and HCT116. METHODS The effects of the teste...