Background: Norhraman is an alkaloid that can damage the nervous system. Objective: This experimental study aimed to investigate effects of prenatal norharman exposure on seizure severity in adult rats. Methods: A total 36 Wistar rats were randomly divided into 3 groups as follows: Control, sham (solvent), and (1000 ug/kg). The treated once daily for 8-18 fetal period. 2 months after birth, kin...

Objective: Antiepileptic drugs (AEDs) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current AEDs therapy. Some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. The aim of the p...

OBJECTIVE Malformations of cortical development are frequent causes of human refractory epilepsy. The freeze-lesion model in rats shows histopathological features similar to those found in human polymicrogyria. Previous studies reported in vitro hyperexcitability in this model, but in vivo epileptogenicity has not been confirmed. METHODS Neocortical freeze lesions were induced in Sprague-Dawl...

In the India there is a good biodiversity in plants. Plants based medicinal products used as integrated part of treatment on most traditional systems medicines. Sesbania grandiflora plant which traditionally for many belongs family Fabaceae. Present study was about investigated Physicochemical and Phytochemical studies selected such grandiflora. For Soxhlet apparatus extraction materials with u...

Epilepsy is a common neurological disorder characterized by seizures that cause neurobiological and behavioral impairment. Caffeine (CAF), which the most widely consumed stimulant in world, reported to influence epileptic antiepileptic drugs, especially topiramate (TPM). The aim of study was optimize zebrafish larvae pentylenetetrazol-induced seizure model for CAF TPM interactions, include dete...