Despite availability of effective therapies, peptic ulcer disease (PUD) remains a major global disease, resulting from a combination of persistent Helicobacter pylori infection and widespread use of nonsteroidal anti-inflammatory drugs. Albeit endoscopy definitely represents the mainstay diagnostic technique, patients presenting to emergency departments with unexplained abdominal pain generally...

BACKGROUND Although the iceA (induced by contact with epithelium) allelic types of Helicobacter pylori have been reported to be associated with peptic ulcer, the importance of iceA on clinical outcomes based on subsequent studies is controversial. The aim of this study was to estimate the magnitude of the risk for clinical outcomes associated with iceA. METHODS A literature search was perform...

O ur understanding of the pathophysiological features of peptic ulcer disease has rapidly evolved during the last century. Early understanding of gastric physiologic characteristics led to logical and time-tested surgical procedures aimed at acid reduction and a lowering of ulcer recurrence rates. A dramatic shift in treatment occurred with the recognition and growing knowledge of Helicobacter ...

BACKGROUND Guidelines on the management of Helicobacter pylori, which cover indications for management and treatment strategies, were produced in 2000. AIMS To update the guidelines at the European Helicobacter Study Group (EHSG) Third Maastricht Consensus Conference, with emphasis on the potential of H pylori eradication for the prevention of gastric cancer. RESULTS Eradication of H pylori...

OBJECTIVES To investigate the combined effects of Helicobacter pylori infection and traditional risk factors for peptic ulcer. METHODS A case-control study was conducted in chemical factories in Shanghai, China. The cases were 500 people with peptic ulcer randomly selected from all staff who met the selection criteria. The controls were 500 employees randomly selected from the same factories ...

Background: It is not yet known which types of Toll-like receptors (TLRs) are most effective in Helicobacter pylori (H. pylori) recognition. It is also not known which gastric zones have the most prominent roles in TLR-mediated bacterial recognition. The aim of this work was to analyze the expression of TLR2 and TLR4 in biopsy specimens from H. pylori-infected patients. Methods: Thirty-eight...

The conventional biomedical model used for medical research and disease management is a linear model in which the cause-effect relationship is important. In contrast, the model used in psychosomatic medicine is a bio-psychosocial model in which much importance is attached to interactions and relationships among various factors, as well as to the individuality of the patients. When peptic ulcer ...

A 54-year-old man visited our emergency department with severe upper abdominal pain. Physical examination revealed muscle guarding and rebound tenderness. Emergent sonography revealed marked thickening of the duodenal wall and a linear hyperechoic band involving the entire wall of the duodenal bulb (Figure 1, arrow). Small hyperechoic spots were found continuously moving from the band towards t...

OBJECTIVES H. pylori infection has been associated with some autoimmune disorders. The aim of this study was to evaluate the serum concentrations of rheumatoid factor and anti-nuclear antibodies in H. pylori-infected peptic ulcer patients, H. pylori-infected asymptomatic carriers and a healthy control group. METHODS A Total of 100 H. pylori-infected peptic ulcer patients, 65 asymptomatic carr...

AIMS To investigate the association of cagA positivity and non-opsonic neutrophil activation capacity in wild-type Helicobacter pylori strains with peptic ulcer disease or chronic gastritis only. METHODS Helicobacter pylori were isolated from antral biopsies of 53 consecutive patients with chronic antral gastritis, of whom 24 had peptic ulcer disease endoscopically. The presence of cagA, a ma...