BACKGROUND Distinguishing the rates of Helicobacter pylori infection in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients with peptic ulcer disease (PUD) from that in PUD patients without CKD is critical. METHODS We first stratified the original 1 million study population according to CKD or ESRD. We retrospectively investigated the incidence of H. pylori infection in P...

Two hundred and thirty five consecutive patients with a life threatening complication of peptic ulceration, who either died or required emergency surgery, have been studied over a 36 month period. Seventy eight of these high risk patients died; 25 at home, 19 in hospital without surgery and 34 postoperatively. Ninety eight patients had bleeding ulcers, 132 perforated ulcers and five had both bl...

Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. The use of natural products for the prevention and treatment of different pathologies is continuou...

BACKGROUND Although Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) are the main causes of peptic ulcers disease (PUD), recently the prevalence of idiopathic peptic ulcer (IPU) is increasing in most parts of the world. The aim of this study was to assess the prevalence of IPU in Kerman, the center of largest province in south-east Iran. METHODS We included 215 patients wi...

Journal of the Malta College of Pharmacy Practice 15 Introduction Following the discovery of the association of peptic ulcer disease with Helicobacter pylori infection there has been a decline in the prevalence of uncomplicated peptic ulcer disease. In contrast, a striking rise in admissions for ulcer haemorrhage and perforation among elderly people is now being observed. This rise has been att...

Gastrointestinal perforations are a complication of 2-10% of duodenal ulcers. There are a variety of etiologies associated with duodenal ulcer formation and its complications. Corticosteroid use is associated with an increased risk of duodenal ulcer perforation, with the first documented case in 1950. Other important medications associated with perforation include NSAIDS and opioids. Beyond med...

Many commonly used non-steroidal anti-inflammatory drugs (NSAIDs) also cause gastrointestinal toxicity, including the development of life-threatening peptic ulcers. We report that mast cell-deficient mice have an extremely high incidence of severe peptic ulceration when exposed to the NSAID piroxicam. This enhanced ulcer susceptibility can be reversed by reconstitution with mast cells. Furtherm...

Peptic ulcer disease (PUD) is considered as one of the common diseases in the world. Treatment of peptic ulcer with synthetic drugs such as proton pump inhibitors, H2 receptor antagonists and other non-steroidal anti-inflammatory drugs has shown adverse effects, relapses, drug interactions. Medicinal plants containing active chemical constituents are useful in prevention and treatment of variou...

BACKGROUND Continued or recurrent bleeding after endoscopic treatment for bleeding ulcer is a major adverse prognostic factor. Identification of such ulcers may allow for alternate treatments. AIM To determine factors predicting treatment failure with combined adrenaline injection and heater probe thermocoagulation. METHODS Consecutive patients with bleeding peptic ulcers who received endos...

Monson, R. R. (Harvard School of Public Health, Boston, Mass. 02115). Familial factors in peptic ulcer. I. The occurrence of ulcer in relatives. Amer. 1. Epid., 1970, 97: 453-459—The occurrence of peptic ulcer in relatives of physicians with a history of ulcer has been compared to that in relatives of physicians without ulcer. About twice as many duodenal ulcers as expected occurred in relative...