The obstacles to the development of therapeutic aptamers for systemic inflammatory diseases, such as nuclease degradation and renal clearance, have not been fully overcome. Here, we report a novel PEGylation method, sbC-PEGylation, which improves the pharmacokinetic properties of RNA aptamers that act against interleukin-17A (IL-17A) in mice and monkeys. sbC-PEGylated aptamers were synthesized ...

Tiger Ditch (formerly Highway 812 Tributary). At the North Fork Canoe Creek confluence ................. +379 +382 City of Henderson, Unincorporated Areas of Henderson County. Approximately 150 feet downstream of Zion Road ...... None +391 Tiger Ditch Tributary 1 .......... At the Tiger Ditch (formerly Highway 812 Tributary) confluence. None +385 City of Henderson, Unincorporated Areas of Hende...

Crawling and scraping activity of three stored-product pests, Sitophilus oryzae (L.) (Coleoptera: Curculionidae), Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), and Stegobium paniceum (L.) (Coleoptera: Anobiidae), and two urban pests, Blattella germanica (L.) (Blattodea: Blattellidae) and Cimex lectularius L. (Hemiptera: Cimicidae), were monitored individually by infrared sensors, mi...

Background Dementia-enriched research studies and normal control-enriched have different recruitment models thus may differ in clinical demographic characteristics. These distinctions can contribute to study findings perspectives. We generated a novel operationalization for cohort status NIA-funded Alzheimer’s Disease Research Centers (ADRC), based on the proportion of participants that were no...

Organization Agility plays a vital role in the survival and sustainability of organization, particularly new normal period. Therefore, objectives this research are: 1. To identify level external forces that influence organizational agility, 2. study impact leadership, workforces, technology capability, creativity innovation agility on airline performance. Data were collected via e-mail in-perso...

The determinant factors of resource conflict between farmers and herdsmen in Benue State were analysed. Objectives to assess the prevalence state determine most responsible for state. Field survey three hundred eighty-two (382) residents was conducted using questionnaire, interview focus group discussion. Data collected analyzed percentage Factor Analysis. Results showed that such as drought, f...

INTRODUCTION Patients after out-of-hospital cardiac arrest (OHCA) benefit from therapeutic hypothermia for 24 hours. The time needed to reach hypothermia (target temperature of 32 degrees C to 34 degrees C) varies widely. In this study, we explore the relation between measures of body composition and the time needed to reach target temperature with hypothermia. METHOD We conducted a prospecti...