نتایج جستجو برای: percutaneous absorption
تعداد نتایج: 187163 فیلتر نتایج به سال:
Neat N-methyl-2-pyrrolidone (NMP) rapidly penetrated into the skin of male Sprague-Dawley rats after in vivo and in vitro topical application. At the two topical doses tested in vivo, no steady state was observed. The maximal absorption fluxes were 10 and 20 mg/cm/h for 20 l/cm and 40 l/cm, respectively. Similar results were observed after in vitro topical application of neat [C]NMP (25–400 l/c...
advantages as an alternative dosage form (i) avoiding firstpass metabolism, (ii) easy discontinuation of administration, and (iii) reduced side effects; however, the stratum corneum, which is the outermost layer of skin, provides a primary barrier to transdermal drug delivery. Pentazocine (PTZ), a relatively short-acting narcotic-antagonist analgesic, is used clinically for the relief of cancer...
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