The development of new therapeutic agents, in any kind of disease, requires either long time or high costs; indeed 10 15 years of research are required to market a drug, resulting in an overall cost of about 1.8 billion dollars [1]. In addition, drug development in oncology is very challenging due to cancer biological complexity, actually comprising several subtypes of diseases carrying differe...

background: the aim of this study was to describe the one-decade experience in percutaneous nephrolithotomy surgery in children with kidney stones in tehran, iran. methods: all patients (less than 18 years old) undergoing percutaneous nephrolithotomy at our referral medical center, were reviewed in this cross-sectional study. all the demographics, surgical data and post-operative information we...

conclusions it seems that, in patients undergoing pncl, sa is as effective and safe as ga. patients who undergo pncl under sa require smaller amounts of analgesic dose and show hemodynamic stability during surgery and recovery time. also, sa technique provides decreased blood loss and shortened surgery as well as anesthesia times compared to ga. results map and heart rate show no significant di...

OBJECTIVE There is still little evidence regarding the type of mattress that is the best for preventing pressure ulcers (PUs). In a Dutch nursing home, a new type of overlay mattress (air inflated visco-elastic foam) was tested to analyze the opportunity for replacement of the normally used static air overlay mattress in its three-step PU prevention protocol In this small pilot the outcome meas...

  Background: This research compares the outcomes of percutaneous technique and open surgical peritoneal dialysis catheter placement in children.   Methods: In this randomized controlled trial, between 2010 and 2011,a total of 35 pediatric uremic patients were enrolled and randomized into two study groups. Follow up data included duration of operation (minute), duration of hospitalization (days...

Background: Open hamstring lengthening (oHSL) is commonly performed to decrease knee contracture and improvegait and posture for children with spastic diplegia. Furthermore, percutaneous hamstring lengthening (pHSL) is alsogaining popularity as an alternative to the open approach. This study aimed to compare the results of pHSL versusoHSL and to determine the efficacy and safe...

Developing a drug de novo is a laborious and costly endeavor. Thus, the repositioning of already approved drugs for the treatment of new diseases is promising and valuable. One computational approach to repositioning exploits the structural similarity of binding sites of known and new targets. Here, we review computational methods to represent and align binding sites. We review available tools,...

Canal switch is a complication following canalith repositioning procedure (CRP) for posterior canal benign paroxysmal positional vertigo (BPPV). Instead of being returned to the utricle, the loose otoconia migrate into the superior or horizontal semicircular canal. Patients remain symptomatic, and treatment can be ineffective unless the switch is recognized and additional repositioning maneuver...