The transcriptome of the brain changes during development, reflecting processes that determine functional specialization of brain regions. We analyzed gene expression, measured using in situ hybridization across the full developing mouse brain, to quantify functional specialization of brain regions. Surprisingly, we found that during the time that the brain becomes anatomically regionalized in ...

Specialization is a growing area of interest in the operating systems community. OS components specialized to some particular circumstance can o er enhanced performance, functionality, or both. Complimentary partial evaluation techniques for automatically specializing programs are also reaching maturity. However, the problem of managing specialization remains: how to specify a specialization, w...

Inheritance allows a class to be specialized and its attributes refined, but implementation specialization can only take place by overriding with manually implemented methods. Automatic program specialization can generate a specialized, efficient implementation. However, specialization of programs and specialization of classes (inheritance) are considered different abstractions. We present a ne...

Run-time specialization is a technique that optimizes a program based on run-time information. In this context, specialization time must be constrained, limiting the possibility to further optimize the specialized code. We present a low-cost methodology for improving the code generated by a run-time specializer. This result is acheived by combining run-time specialization with another form of a...