Perioperative anaphylactic reactions are immediate, hypersensitive reactions that are potentially life-threatening resulting from a sudden release of mediators from mast cells and basophiles, due to either immune (IgE or non-IgE mediated) or non-immune mechanisms. The most frequent causing agents are neuromuscular blocking agents (NMBAs), latex and antibiotics, with latex being the first cause ...

The perioperative management of patients at risk for cardiovascular diseases who undergo non-cardiac surgery has been subject of debate over the past few decades and is still of great interest. An adequate perioperative management may modify postoperative mortality and morbidity and may improve the long-term prognosis. The purpose of this review is to examine the present day knowledge regarding...

INTRODUCTION Accumulating evidence suggests that enhanced inflammatory responses contribute to the pathogenesis of postoperative cognitive dysfunction (POCD). Blood transfusion can trigger an enhancement of acute inflammatory responses. Therefore, we hypothesized that perioperative blood transfusion is associated with a higher risk of POCD in aged patients following total hip replacement surger...

Surgery in the patient with diabetes mellitus is relatively common, as the numbers of persons with diabetes is increasing and diabetes predisposes to medical conditions that require surgical intervention. An estimated 25% of diabetic patients will require surgery, and advances in perioperative care of these patients allow them to safely undergo the most complicated surgical procedures. We will ...

OBJECTIVE To evaluate the implementation and effectiveness of an internet-based perioperative care programme for patients following gynaecological surgery for benign disease. DESIGN Stepped-wedge cluster randomised controlled trial. SETTING Secondary care, nine hospitals in the Netherlands, 2011-2014. PARTICIPANTS 433 employed women aged 18-65 years scheduled for hysterectomy and/or lapar...

Recently, the ERBP (European Renal Best Practice) guideline on kidney donor and recipient evaluation and perioperative care has been published and disseminated to the international nephrology community. This guideline aims at providing evidence-based recommendations on the evaluation of the kidney transplant candidate. They evaluate the immunologic workup of kidney donors and recipients, they r...

OBJECTIVE To investigate the association of the 2011 American Academy of Otolaryngology Head and Neck Surgery guidelines with perioperative care processes and outcomes in children undergoing tonsillectomy. METHODS We conducted a retrospective cohort study of otherwise healthy children undergoing tonsillectomy between January 2009 and January 2013 at 29 US children's hospitals participating in...

• Objective: To assess nurses’ opinions of a hospitalistorthopedic team (HOT) model of perioperative care. • Design: Paper survey distributed quarterly as a portion of a larger randomized controlled trial. • Setting: Rochester Methodist Hospital (Mayo Clinic), an academic, primarily elective surgical hospital in

In the United States, more than 33 million patients undergo noncardiac surgery each year, at a cost of 450 000 million dollars per year. Approximately 4% of these patients present perioperative complications, at an additional cost of 25 000 million dollars per year.1 The number of cardiovascular complications arising from non-cardiac surgery exceeds 1 million patients worldwide.2 Due to the inc...

PURPOSE Intranasal dexmedetomidine is an effective sedative for premedication and is regularly used to reduce preoperative tension and anxiety in children. This study aimed to assess the effect of intranasally adjunctive dexmedetomidine on perioperative sedative and analgesic requirements in adults. MATERIALS AND METHODS Patients were randomly divided into four groups to receive preoperative ...