Objective(s): To investigate the systemic and local immune status of two surgical rat models of sciatic nerve injury, a crushed sciatic nerve, and a sciatic nerve transection Materials and Methods:Twenty-four adult male Sprague-Dawley rats were randomly divided into three groups: sham-operation (control group), sciatic nerve crush, and sciatic nerve transaction. Sciatic nerve surgery was perfor...

introduction: epineural suture and autologous graft are two routine techniques in peripheral nerve surgery. however, their efficiency can be highly limited depending on the type of lesion and the gap between two nerve stumps and because of deficient proper nerve donors. so much interest has been focused on the development of alternative instruments for bridging the nerve gaps. in the present st...

Background: Although peripheral nerves show capacity for regeneration after injury to a certain extent, the extent of regeneration is not remarkable. Previous studies have suggested that through the production of growth factors or extracellular matrix components, mesenchymal stem cells may enhance nerve regeneration.Objectives: In the present study, the therapeutic potenc...

excessive scarring; paralleling the process in tendon reconstruction of the hand. Inspired by the advantages of the two-stage technique in tendon grafting and with encouraging preliminary results, we aimed to investigate the two-stage nerve grafting technique as an alternative method of secondary nerve repair. Methods:  Thirty female rats (~200 g) were randomly distributed into two groups (n=15...

peripheral nerve injuries caused by traffic accidents, resections of tumors or iatrogenic side effects of the surgeries are few of the most common form of trauma occurring with up to 500,000 cases each year in iran. conventional strategies including nerve coaptation, and the application of autografts, allografts and xenografts are restricted due to the limited availability of donors, immune-rej...

INTRODUCTION Neurofibromatosis type 2 (NF2) is mainly associated with central nervous system (CNS) tumors. Peripheral nerve involvement is described in symptomatic patients, but evidence of subclinical peripheral nerve involvement is scarce. METHODS We conducted a cross-sectional pilot study in 2 asymptomatic and 3 minimally symptomatic patients with NF2 to detect subclinical peripheral nerve...

Key points † Serious complications of peripheral nerve blocks include nerve injury, catheter infection, bleeding, and LAST. † Intraneural injection occurs frequently with nerve stimulator or ultrasound-guided techniques. It is rarely associated with nerve injury. † Lipid emulsion therapy is effective in treating severe LAST. Summary Complications of peripheral nerve blocks are fortunately rare,...