Digital nerve injuries are common; injuries of the common digital nerves are less frequent than those involving the proper digital nerves. Traditional techniques used to reconstruct peripheral nerves are: direct suture, autologous nerve grafts, autologous vein grafts, vascularised nerve graft and alloplastic nerve grafts. Autologous nerve grafts remain the most common conduits for segmental def...

Following peripheral nerve trauma, no technique induces axons to regenerate across a long nerve gaps and restore neurological function. The standard clinical “gold standard” technique for bridging nerve gaps is a graft of pure sensory nerve. However, sensory nerve grafts have many limitations because they only induce good axon regeneration across gaps <2 cm in length, for the nerves repaired <2...

PURPOSE To examine the relationship between the distance of axotomy and axonal regeneration of injured retinal ganglion cells (RGCs) systematically and the effect of a predegenerated (pretransected or precrushed) peripheral nerve (PN) graft on axonal regeneration of RGCs axotomized at a definite distance (0.5 mm from the optic disc) in comparison with a normal PN graft. METHODS The optic nerv...

In the current research, to find if the combination of chitosan nerve conduits seeded with autologous bone marrow mononuclear cells (BM-MNCs) can be used to bridge 30 mm long peroneal nerve defects in goats, 15 animals were separated into BM-MNC group (n = 5), vehicle group (n = 5), and autologous nerve graft group (n = 5). 12 months after the surgery, animals were evaluated by behavioral obser...

Peripheral nerves are essential connections between the central nervous system and muscles, autonomic structures and sensory organs. Their injury is one of the major causes for severe and longstanding impairment in limb function. Acute peripheral nerve lesion has an important inflammatory component and is considered as ischemia-reperfusion (IR) injury. Surgical repair has been the standard of c...

Background. Peripheral nerve injury treatment options are limited to primary nerve repair, nerve grafting, and tendon transfers. In this case, a large suitable donor site was easily accessible and delayed grafting was indicative of poor prognosis. Case Description. A 25-year-old soldier presented to a military hospital in Afghanistan following a roadside bomb attack. The patient had a medial sh...

Background: Multiple sclerosis (MS) is known to affect essentially the central nervous system; however, peripheral nerve involvement, as an additional cause of disability, has been recently noticed. Objectives: This study was aimed to perform detailed electrodiagnostic assessments in MS patients to evaluate peripheral nervous system involvement. Materials and Methods: A total of eighty MS...

BACKGROUND Long-gap peripheral nerve defects arising from tumor, trauma, or birth-related injuries requiring nerve reconstruction are currently treated using nerve autografts and nerve allografts. Autografts are associated with limited supply and donor-site morbidity. Allografts require administration of transient immunosuppressants, which has substantial associated risks. To overcome these lim...

In microsurgical nerve repair, the epineural sleeve technique can be used to bridge short nerve defects and to coverthe coaptation site with the epineurium of the nerve stump. The epineurium serves as a mechanical aid to reducegap size, and increase repair strength, effectively assisting nerve regeneration.This article presents a 32-year-old patient who experienced complete transection of the m...