This study characterized the effects of diabetes and/or ischemia on epidermal growth factor receptor, EGFR, and/or erbB2 signaling pathways on cardiac function. Isolated heart perfusion model of global ischemia was used to study the effect of chronic inhibition or acute activation of EGFR/erbB2 signaling on cardiac function in a rat model of type-1 diabetes. Induction of diabetes with streptozo...

Objectives. This study compared the effects of rosuvastatin on left ventricular infarct size in mice following permanent coronary occlusion versus 60 minutes ischemia/24 hours reperfusion and evaluated the effects of rosuvastatin on potential beneficial mechanisms of infarct size reduction including neutrophil accumulation, NO synthase expression and stem cell mobilization following ischemia an...

objective: several studies have shown that chichorium intybus l. (c. intybus) which possesses flavonoid compounds has an effective role in treatment of cardiovascular diseases. contractile dysfunction mostly occurs after acute myocardial infarction, cardiac bypass surgery, heart transplantation and coronary angioplasty. the aim of the present study was to investigate the effect of aqueous extra...

BACKGROUND AND PURPOSE The efficacy of hypothermic intervention for permanent focal ischemia has yet to be clarified. This study investigated the effect of a prolonged moderate or mild hypothermia on permanent focal ischemia in rats. METHODS Two permanent focal ischemia models in male Sprague-Dawley rats were used. Moderate (30 degrees C, in experiment 1) or mild (33 degrees C, in experiment ...

Objective(s): The current management of coronary artery disease (CAD) relies on three major therapeutic options, namely medication, percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). However, severe CAD that is not indicated for PCI or CABG still bears a poor prognosis due to the lack of effective treatments. In 2006, extracorporeal cardiac shock wave (SW) the...

OBJECTIVE To determine the need for long-term pacing and optimum mode of pacing in cardiac transplant recipients. DESIGN (a) A retrospective review of patient records. (b) A prospective study of pacemaker use by 24 hour ambulatory electrocardiography before and after reprogramming to minimise use of pacemakers. SETTING Outpatient clinic, supra-regional cardiopulmonary transplant unit. PAT...

BACKGROUND Diabetics remain at high risk of cardiovascular disease and mortality despite advancements in medical therapy. Noninvasive cardiac risk profiling is often more difficult in diabetics owing to the prevalence of silent ischemia with unrecognized myocardial infarction, reduced exercise capacity, nondiagnostic electrocardiographic changes, and balanced ischemia from diffuse epicardial co...

This study compared the effects of rosuvastatin on left ventricular infarct size in mice after permanent coronary occlusion vs. 60 min of ischemia followed by 24 h of reperfusion. Statins can inhibit neutrophil adhesion, increase nitric oxide synthase (NOS) expression, and mobilize progenitor stem cells after ischemic injury. Mice received blinded and randomized administration of rosuvastatin (...

Non-occlusive mesenteric ischemia (NOMI) is a severe complication in patients after cardiac arrest (CA). The diagnosis complicated, the treatment options are limited. Given susceptibility of enterocytes to ischemia, incidence and severity NOMI post-resuscitation period may reflect intensity duration both subsequent reperfusion injury. considered be associated with adverse neurological outcomes ...

introdution: stroke is one of the most common diseases caused by occlusion or rupture of blood vessels in brain. it brings heavily loads for families and societies. although some new strategies including treatment of tissue plasminogen activator have been applied in the clinic, these methods do not have perfect effect. accordingly, more effective therapeutic strategies need to be developed. thi...