Although there have been suggestions that prenatal factors could affect crown dimensions (Bailit and Sung, Archs Oral Biol 13:155-166, 1968; Cohen, Baum, Garn, Osario and Nagy, in: Orofacial Growth and Development, Dahlberg and Graber, eds., Mouton Publishers, The Hague, 1977, pp 119-126), limitations of sample size and investigative design restrict conclusions on the magnitude of the influence...

Abstract Neonatal screening for congenital primary hypothyroidism (CH) may not distinguish between transient (TCH) and permanent dysfunction (PCH), causing potential overtreatment concerns in affected families. To specify the indication interruption of therapy, we analysed German registry “HypoDok” infants with CH, which oversees 1625 patients from 49 participating centres Germany Austria 1997 ...

PURPOSE We investigated the clinical course of infants with congenital heart disease (CHD) who experienced thyroid dysfunction within 100 days of birth. METHODS We performed retrospective medical reviews of 54 CHD patients (24 male patients) who underwent a thyroid function test (TFT) between January 2007 and July 2016. Data were collected on birth history, diagnosis of CHD, underlying chromo...

In babies with congenital hypothyroidism, goiter and respiratory distress (due to upper airway compression/hypothyroidism) are rarely encountered as the first presenting signs. Computerized Tomography of neck revealed enlargement all thyroid gland lobes further laboratory hypothyroidism. Thyroid hormone replacement therapy was initiated early, which resulted in a significant reduction regressio...

Primary hypothyroidism is a graded phenomenon with a wide spectrum of severity between subclinical hypothyroidism and overt hypothyroidism. Patients with biochemically severe hypothyroidism may present with only mild clinical manifestations, whereas some patients with moderate changes in thyroid hormones may present with severe signs of tissue hypothyroidism. The measurement of pituitary thyroi...

Iodine is an essential element for thyroid hormone synthesis. The thyroid gland has the capacity and holds the machinery to handle the iodine efficiently when the availability of iodine becomes scarce, as well as when iodine is available in excessive quantities. The latter situation is handled by the thyroid by acutely inhibiting the organification of iodine, the so-called acute Wolff-Chaikoff ...

TWO TRABS: TSBAb and TSAb. TSBAb causes hypothyroidism. TSAb causes Graves' hyperthyroidism. TSBAb and TSAb block TSH-binding to cells as TRAb, measured as TSH-binding inhibitory immunoglobulin (TBII). We reevaluate TSBAb and TSAb. We studied TSBAb, TSAb, and TBII over 10 years in 34 TSBAb-positives with hypothyroidism and in 98 TSAb-positives with hyperthyroidism. Half of the 34 TSBAb-positive...

Autoimmune diseases accompanied by the development of hypothyroidism (Hashimoto's thyroiditis) and hyperthyroidism (Graves' disease) are one most common disorders thyroid gland. Hypothyroidism is a clinical syndrome that occurs as result hormone deficiency. Hyperthyroidism excessive activity gland hypersecretion hormones. In simple terms, to achieve euthyroid state in both syndromes, two drugs ...

Results Of the 610 patients diagnosed primarily with CH; 554 (89.1%) patients were diagnosed to have permanent CH, and 66 (10.8%) patients were diagnosed to have transient CH. The median TSH levels before treatment were significantly higher in patients with permanent CH than transient CH (median 58.1:24.1 μIU/mL). Male to female ratio was 1:1.2 (35:31) in transient CH. Of the 66 children diagno...