Strategy and Mechanism for Controlling Direction of Defect Evolution in Graphene: Preparation of High-Quality DefectHealed and Hierarchically Porous Graphene Kecheng Cao,a Yin Tian, a Yongzhi Zhang,b Xiaodan Yang, a Chiyao Bai, a Yue Luo, a Xiaosheng Zhao, a Lijian Ma, a,* and Shoujian Li a,* a College of Chemistry, Key Laboratory of Radiation Physics & Technology, and b Institute of New Energy...

BACKGROUND AND THE PURPOSE OF THE STUDY As a novel drug in the treatment of cardiac diseases, dl-praeruptorin A (Pd-Ia) is the major active component of traditional herbal medicine Peucedanum praeruptorum Dunn and is metabolized primarily via cytochrome P450 isozymes (CYP) 3A1 and 3A2 in rats. In the present study, the influence of liver cirrhosis on pharmacokinetics of Pd-Ia and hepatic mRNA e...

There is increasing interest in the use of herbal products to maintain human health. Plants contain a wide variety of compounds that may have biological activities including anticancer effect (Boik, 2001). There are many kinds of herbal plants in the Ryukyu Islands, Okinawa, Japan. Some of them have been used for the treatment of patients who are affected with insomnia, severe infections, or en...

We recently reported that Praeruptorin C effectively transactivated the mRNA, protein expression, and catalytic activity of CYP3A4 via the CAR-mediated pathway, but whether and how PC could affect the expression and catalytic activity of CYP3A4 via PXR pathway remains unknown. Therefore, in this study, the effect of PC on the CYP3A gene expression was investigated in mice primary hepatocytes af...

Metastatic cancers spread from their site of origin (the primary site) to other parts of the body. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is important in metastatic cancers as it plays a major role in cancer cell invasion. The present study examined the inhibitory effect of an ethanol extract of Peucedanum japonicum Thunb. (PJT) on MMP-9 expression and the ...

BACKGROUND The ethanol extract of KOTMIN13, composed of Inula japonica Flowers, Trichosanthes kirilowii Semen, Peucedanum praeruptorum Radix, and Allium macrostemon Bulbs, was investigated for its anti-asthmatic and anti-allergic activities. METHODS The anti-asthmatic effects of KOTMIN13 were evaluated on ovalbumin (OVA)-induced murine asthma model. Anti-allergic properties of KOTMIN13 in bon...